TY - JOUR
T1 - Emerging need of pharmacokinetics in Ayurvedic system of medicine
AU - Kaliappan, Ilango
AU - Kammalla, Ananth Kumar
AU - Ramasamy, Mohan Kumar
AU - Agrawal, Aruna
AU - Dubey, Govind Prasad
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2013/9
Y1 - 2013/9
N2 - Ayurveda is the most ancient system of traditional medicine of the world has been practicing in India. It has been facing constant challenges like standardization and pharmacokinetic profile of biomarkers in the Ayurvedic formulations. Due to these challenges there will be a potential decrease in the global herbal market. Presently Indian herbal market is about US $1.1 billion whereas Chinese herbal market is about US $10 billion per annum. Thus there is an urgent need of standardization and pharmacokinetics of the Ayurvedic formulations in order to achieve the uphold position in the global market. Pharmacokinetics which deals with the absorption, distribution, metabolism and excretion of the biomarkers or the new drug entity is the one of the regulatory requirement for an investigational new drug approval. Bioactive guided pharmacokinetic approach method is needed for Ayurvedic system of medicine to determine the pharmacokinetics of relevant markers in the formulation having number of markers. Also non compartmental analysis method should be applied for the analysis of pharmacokinetics of biomarkers from Ayurvedic formulations for successful pharmacokinetic evaluation. In this review we have explored the importance of pharmacokinetics in Ayurvedic system of medicine and integrated approaches for the pharmacokinetics in Ayurvedic system of medicine.
AB - Ayurveda is the most ancient system of traditional medicine of the world has been practicing in India. It has been facing constant challenges like standardization and pharmacokinetic profile of biomarkers in the Ayurvedic formulations. Due to these challenges there will be a potential decrease in the global herbal market. Presently Indian herbal market is about US $1.1 billion whereas Chinese herbal market is about US $10 billion per annum. Thus there is an urgent need of standardization and pharmacokinetics of the Ayurvedic formulations in order to achieve the uphold position in the global market. Pharmacokinetics which deals with the absorption, distribution, metabolism and excretion of the biomarkers or the new drug entity is the one of the regulatory requirement for an investigational new drug approval. Bioactive guided pharmacokinetic approach method is needed for Ayurvedic system of medicine to determine the pharmacokinetics of relevant markers in the formulation having number of markers. Also non compartmental analysis method should be applied for the analysis of pharmacokinetics of biomarkers from Ayurvedic formulations for successful pharmacokinetic evaluation. In this review we have explored the importance of pharmacokinetics in Ayurvedic system of medicine and integrated approaches for the pharmacokinetics in Ayurvedic system of medicine.
KW - Ayurveda
KW - Herbal market
KW - Non compartmental model
KW - Pharmacokinetics
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U2 - 10.7897/2277-4343.04503
DO - 10.7897/2277-4343.04503
M3 - Review article
AN - SCOPUS:84897924405
SN - 2277-4343
VL - 4
SP - 647
EP - 651
JO - International Journal of Research in Ayurveda and Pharmacy
JF - International Journal of Research in Ayurveda and Pharmacy
IS - 5
ER -