TY - JOUR
T1 - Emerging and re-emerging Rickettsioses
T2 - Endothelial cell infection and early disease events
AU - Walker, David H.
AU - Ismail, Nahed
PY - 2008/5
Y1 - 2008/5
N2 - Rickettsiae cause some of the most severe human infections, including epidemic typhus and Rocky Mountain spotted fever. Substantial progress has been made in research into the genomics, vector relationships, pathogenesis and immunity of these obligate, intracellular, arthropod-transmitted bacteria. This Review summarizes our understanding of the early and late events in pathogenesis and immunity, modulation of the host response to rickettsial infection by the vector, host defence, virulence mechanisms and rickettsial manipulation of host cells.
AB - Rickettsiae cause some of the most severe human infections, including epidemic typhus and Rocky Mountain spotted fever. Substantial progress has been made in research into the genomics, vector relationships, pathogenesis and immunity of these obligate, intracellular, arthropod-transmitted bacteria. This Review summarizes our understanding of the early and late events in pathogenesis and immunity, modulation of the host response to rickettsial infection by the vector, host defence, virulence mechanisms and rickettsial manipulation of host cells.
UR - http://www.scopus.com/inward/record.url?scp=42349101098&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=42349101098&partnerID=8YFLogxK
U2 - 10.1038/nrmicro1866
DO - 10.1038/nrmicro1866
M3 - Review article
C2 - 18414502
AN - SCOPUS:42349101098
SN - 1740-1526
VL - 6
SP - 375
EP - 386
JO - Nature Reviews Microbiology
JF - Nature Reviews Microbiology
IS - 5
ER -