Embryology and pathophysiology of the Chiari i and II malformations

Mohammadali M. Shoja, R. Shane Tubbs, W. Jerry Oakes

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations


Hindbrain herniation is only one component of the Chiari malformations. These malformations often have other associated intracranial anomalies and malformations of the vertebral column. Depending on embryologic timing, -herniation of the cerebellar vermis or tonsils occurs. Additionally, the herniated hindbrain may include the medulla oblongata and fourth ventricle. Currently, no single theory explains all of the malformations seen in the Chiari I and II malformations. These pathologic derailments seem to result from a heterogeneous spectrum of ontogenetic errors and pathological mechanisms, which share some common phenotypical presentations. In this chapter, the theories pertinent to the embryology and pathophysiology of Chiari I and II malformations and their associated anomalies are discussed.

Original languageEnglish (US)
Title of host publicationThe Chiari Malformations
PublisherSpringer New York
Number of pages18
ISBN (Electronic)9781461463696
ISBN (Print)1461463688, 9781461463689
StatePublished - Mar 1 2013
Externally publishedYes


  • Arnold-Chiari
  • Cerebellum
  • Hindbrain herniation
  • Posterior cranial fossa
  • Tonsillar ectopia

ASJC Scopus subject areas

  • General Medicine


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