Elevated Microparticle Tissue Factor Activity Is Associated with Carotid Artery Plaque in HIV-Infected Women

Juan Lin, Xiaonan Xue, Kathryn Anastos, Mardge H. Cohen, Stephen J. Gange, Jason M. Lazar, Chenglong Liu, Wendy J. Mack, Phyllis C. Tien, Cathy Tilley, Howard N. Hodis, Alan L. Landay, Russell P. Tracy, Robert C. Kaplan, David B. Hanna

Research output: Contribution to journalArticlepeer-review


Background:Expression of tissue factor (TF) on the surface of activated monocytes may trigger thrombosis, leading to clotting risk, inflammation, and atherosclerosis. TF-positive microparticles (MP-TF) represent a functionally active form of TF that may be promulgated by long-term HIV infection. We hypothesized that greater MP-TF activity is associated with carotid artery plaque in HIV+ women.Setting:In a case-control study nested within the Women's Interagency HIV Study (WIHS), eligible HIV+ participants underwent B-mode carotid artery ultrasound at 2 study visits occurring 7 years apart. Cases were defined by the presence of at least 1 carotid artery plaque assessed at either visit. Cases were matched 1:2 to controls who were found not to have carotid artery plaques.Methods:Conditional logistic regression estimated the association of MP-TF activity with the presence of carotid artery plaque, adjusting for demographic and behavioral characteristics, HIV-related factors, cardiometabolic risk factors, and serum inflammation biomarkers (high-sensitivity C-reactive protein, IL-6, sCD14, sCD163, Gal-3, and Gal-3BP).Results:Elevated MP-TF activity (>0.537 pg/mL) was found to be significantly associated with greater odds of plaque (adjusted odds ratio 3.86, 95% confidence interval: 1.06 to 14.07, P = 0.04). The association was attenuated after further adjustment for IL-6 but was unaffected by adjustment for other biomarkers including those denoting monocyte activation.Conclusions:Our findings suggest a link among HIV infection, innate immune system perturbation, coagulation, and atherosclerosis.

Original languageEnglish (US)
Pages (from-to)36-43
Number of pages8
JournalJournal of Acquired Immune Deficiency Syndromes
Issue number1
StatePublished - May 1 2019
Externally publishedYes


  • atherosclerosis
  • carotid plaque
  • coagulation
  • HIV infection
  • tissue factor
  • women

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)


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