El estrés crónico, ¿factorde riesgo para la enfermedad de Alzheimer?

Translated title of the contribution: Is chronic stress a risk factor for Alzheimer's disease?

Mary García-Acero, Mauricio Avila-Guerra, Cristina Blanco, Jorge Mario Rodríguez-Fernández, Bryann Avendaño, David Casilimas

Research output: Contribution to journalReview articlepeer-review


Alzheimer's disease (AD) is a progressive neurodegenerative disorder, with epidemiological importance due to the high prevalence of people affected worldwide. Over time, various hypotheses have been raised in the pathophysiology and etiology of the disease and now the study of this disorder, is tackled from a multi-causal perspective, taking into account different etiological factors, among which are: genetics, oxidative stress, intracellular calcium dynamics, vascular effects, inflammation and stress, among others. The following literature review, aims to show studies that correlate stress as a risk factor in AD, recognizing the pathophysiological findings of AD, due to augmentation on glucocorticoids by chronic stress and the subsequent alteration of the hypothalamic-pituitary-adrenal axis. Critical view of these findings according to the literature.

Translated title of the contributionIs chronic stress a risk factor for Alzheimer's disease?
Original languageSpanish
Pages (from-to)69-77
Number of pages9
JournalRevista Ecuatoriana de Neurologia
Issue number1-3
StatePublished - 2012
Externally publishedYes


  • Alzheimer's disease
  • Depression
  • Glucocorticoids
  • Hypothalamic-pituitary- adrenal axis
  • Neurofibrillary tangles
  • Stress
  • Tau protein

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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