TY - JOUR
T1 - Efficacy of post-exposure treatment of yellow fever with ribavirin in a hamster model of the disease
AU - Sbrana, Elena
AU - Xiao, Shu Yuan
AU - Guzman, Hilda
AU - Ye, Mengyi
AU - Travassos Da Rosa, Amelia P.A.
AU - Tesh, Robert B.
PY - 2004/9
Y1 - 2004/9
N2 - Ribavirin was evaluated as a potential treatment of yellow fever (YF) in a hamster model of the disease. Ribavirin treatment during the first five days after YF virus infection improved survival, reduced tissue damage in target organs (liver and spleen), prevented hepatocellular steatosis, and normalized alanine aminotransferase levels. The results of this study suggest that ribavirin may be effective in the early treatment of YF, and that its mechanism of action in reducing liver pathology in YF virus infection may be similar to that observed with ribavirin in the treatment of chronic hepatitis C virus infection.
AB - Ribavirin was evaluated as a potential treatment of yellow fever (YF) in a hamster model of the disease. Ribavirin treatment during the first five days after YF virus infection improved survival, reduced tissue damage in target organs (liver and spleen), prevented hepatocellular steatosis, and normalized alanine aminotransferase levels. The results of this study suggest that ribavirin may be effective in the early treatment of YF, and that its mechanism of action in reducing liver pathology in YF virus infection may be similar to that observed with ribavirin in the treatment of chronic hepatitis C virus infection.
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U2 - 10.4269/ajtmh.2004.71.306
DO - 10.4269/ajtmh.2004.71.306
M3 - Article
C2 - 15381811
AN - SCOPUS:4544346116
SN - 0002-9637
VL - 71
SP - 306
EP - 312
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 3
ER -