Efficacy of a heparin removal device in comparison with protamine after hypothermic cardiopulmonary bypass

Weike Tao; Donald J. Deyo; Robert L. Brunston; Roger A. Vertrees; Tonya L. Grochoske; Joseph B. Zwischenberger

doi:10.1097/00002480-199709000-00100

Efficacy of a heparin removal device in comparison with protamine after hypothermic cardiopulmonary bypass

Weike Tao, Donald J. Deyo, Robert L. Brunston, Roger A. Vertrees, Tonya L. Grochoske, Joseph B. Zwischenberger

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

To reduce the risks of protamine reactions after cardiopulmonary bypass (CPB), a heparin removal device (HRD) with plasma separation and poly-L-lysine (PLL) affinity adsorption was developed. To compare the efficacy of HRD with that of protamine, blood coagulation variables were evaluated in a swine model of CPB. It is concluded that the HRD is capable of predictable reversal of systemic heparinization after CPB, and is an alternative to achieve heparin clearance in subjects who may develop adverse reactions to protamine.

Original language	English (US)
Pages (from-to)	M825-M830
Journal	ASAIO Journal
Volume	43
Issue number	5
DOIs	https://doi.org/10.1097/00002480-199709000-00100
State	Published - 1997
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Bioengineering
Biomaterials
Biomedical Engineering

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abstract = "To reduce the risks of protamine reactions after cardiopulmonary bypass (CPB), a heparin removal device (HRD) with plasma separation and poly-L-lysine (PLL) affinity adsorption was developed. To compare the efficacy of HRD with that of protamine, blood coagulation variables were evaluated in a swine model of CPB. It is concluded that the HRD is capable of predictable reversal of systemic heparinization after CPB, and is an alternative to achieve heparin clearance in subjects who may develop adverse reactions to protamine.",

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AU - Tao, Weike

AU - Deyo, Donald J.

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AU - Vertrees, Roger A.

AU - Grochoske, Tonya L.

AU - Zwischenberger, Joseph B.

PY - 1997

Y1 - 1997

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AB - To reduce the risks of protamine reactions after cardiopulmonary bypass (CPB), a heparin removal device (HRD) with plasma separation and poly-L-lysine (PLL) affinity adsorption was developed. To compare the efficacy of HRD with that of protamine, blood coagulation variables were evaluated in a swine model of CPB. It is concluded that the HRD is capable of predictable reversal of systemic heparinization after CPB, and is an alternative to achieve heparin clearance in subjects who may develop adverse reactions to protamine.

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Efficacy of a heparin removal device in comparison with protamine after hypothermic cardiopulmonary bypass

Abstract

ASJC Scopus subject areas

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