Effects of traumatic brain injury on cognitive functioning and cerebral metabolites in HIV-infected individuals

Kenny Lin, Michael J. Taylor, Robert Heaton, Donald Franklin, Terry Jernigan, Christine Fennema-Notestine, Allen McCutchan, J. Hampton Atkinson, Ronald J. Ellis, Justin McArthur, Susan Morgello, David Simpson, Ann C. Collier, Christina Marra, Benjamin Gelman, David Clifford, Igor Grant

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


We explored the possible augmenting effect of traumatic brain injury (TBI) history on HIV (human immunodeficiency virus) associated neurocognitive complications. HIV-infected participants with self-reported history of definite TBI were compared to HIV patients without TBI history. Groups were equated for relevant demographic and HIV-associated characteristics. The TBI group evidenced significantly greater deficits in executive functioning and working memory. N-acetylaspartate, a putative marker of neuronal integrity, was significantly lower in the frontal gray matter and basal ganglia brain regions of the TBI group. Together, these results suggest an additional brain impact of TBI over that from HIV alone. One clinical implication is that HIV patients with TBI history may need to be monitored more closely for increased risk of HIV-associated neurocognitive disorder signs or symptoms.

Original languageEnglish (US)
Pages (from-to)326-334
Number of pages9
JournalJournal of Clinical and Experimental Neuropsychology
Issue number3
StatePublished - Mar 2011


  • HIV associated neurocognitive disorder
  • Head injury
  • Magnetic resonance spectroscopy
  • N-acetylaspartate
  • Neuropsychological performance

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuropsychology and Physiological Psychology
  • Neurology
  • Clinical Psychology


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