TY - JOUR
T1 - Effects of traumatic brain injury on cognitive functioning and cerebral metabolites in HIV-infected individuals
AU - Lin, Kenny
AU - Taylor, Michael J.
AU - Heaton, Robert
AU - Franklin, Donald
AU - Jernigan, Terry
AU - Fennema-Notestine, Christine
AU - McCutchan, Allen
AU - Atkinson, J. Hampton
AU - Ellis, Ronald J.
AU - McArthur, Justin
AU - Morgello, Susan
AU - Simpson, David
AU - Collier, Ann C.
AU - Marra, Christina
AU - Gelman, Benjamin
AU - Clifford, David
AU - Grant, Igor
N1 - Funding Information:
CNS HIV Antiretroviral Therapy Effects Research (CHARTER) is supported by award N01 MH22005 from the National Institutes of Health. Address correspondence to Igor Grant, Department of Psychiatry (0680), School of Medicine, University of California, San Diego, La Jolla, CA 92093–0680, USA (E-mail: [email protected]).
PY - 2011/3
Y1 - 2011/3
N2 - We explored the possible augmenting effect of traumatic brain injury (TBI) history on HIV (human immunodeficiency virus) associated neurocognitive complications. HIV-infected participants with self-reported history of definite TBI were compared to HIV patients without TBI history. Groups were equated for relevant demographic and HIV-associated characteristics. The TBI group evidenced significantly greater deficits in executive functioning and working memory. N-acetylaspartate, a putative marker of neuronal integrity, was significantly lower in the frontal gray matter and basal ganglia brain regions of the TBI group. Together, these results suggest an additional brain impact of TBI over that from HIV alone. One clinical implication is that HIV patients with TBI history may need to be monitored more closely for increased risk of HIV-associated neurocognitive disorder signs or symptoms.
AB - We explored the possible augmenting effect of traumatic brain injury (TBI) history on HIV (human immunodeficiency virus) associated neurocognitive complications. HIV-infected participants with self-reported history of definite TBI were compared to HIV patients without TBI history. Groups were equated for relevant demographic and HIV-associated characteristics. The TBI group evidenced significantly greater deficits in executive functioning and working memory. N-acetylaspartate, a putative marker of neuronal integrity, was significantly lower in the frontal gray matter and basal ganglia brain regions of the TBI group. Together, these results suggest an additional brain impact of TBI over that from HIV alone. One clinical implication is that HIV patients with TBI history may need to be monitored more closely for increased risk of HIV-associated neurocognitive disorder signs or symptoms.
KW - HIV associated neurocognitive disorder
KW - Head injury
KW - Magnetic resonance spectroscopy
KW - N-acetylaspartate
KW - Neuropsychological performance
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U2 - 10.1080/13803395.2010.518140
DO - 10.1080/13803395.2010.518140
M3 - Article
C2 - 21229435
AN - SCOPUS:79952615126
SN - 1380-3395
VL - 33
SP - 326
EP - 334
JO - Journal of Clinical and Experimental Neuropsychology
JF - Journal of Clinical and Experimental Neuropsychology
IS - 3
ER -