Effects of the 5-HT(2C/2B) antagonist SB 206553 on hyperactivity induced by cocaine

Andrew C. McCreary, Kathryn A. Cunningham

Research output: Contribution to journalArticlepeer-review

78 Scopus citations


Serotonin (5-HT) appears to play a modulatory role in the behavioral effects of cocaine, although the impact of 5-HT(2C) receptors in this control has not been fully established. The aim of the present study was to establish whether acute pretreatment with the selective 5-HT(2C/2B) antagonist SB 206553 (1, 2, and 4 mg/kg IP) altered hyperactivity induced by cocaine (15 mg/kg, IP) using an open field activity system which recorded central, peripheral, and rearing activity. Pretreatment with 1 and 2 mg/kg of SB 206553 attenuated cocaine-induced central and peripheral activity, respectively; rearing was also attenuated by the latter dose. However, the 4-mg/kg dose of SB 206553 significantly enhanced the effects of cocaine on peripheral activity. Based upon the present observations and an interpretation of previous research to implicate 5-HT(2C) receptor control of the dopamine (DA) mesoaccumbens pathways in behavior, a thorough and systematic analysis of the role of 5-HT(2C) (and 5-HT(2B)) receptors in psychostimulant-induced behaviors is warranted. Copyright (C) 1999 American College of Neuropsychopharmacology.

Original languageEnglish (US)
Pages (from-to)556-564
Number of pages9
Issue number6
StatePublished - Jun 1999
Externally publishedYes


  • 5-HT(2B)
  • 5-HT(2C)
  • Cocaine
  • Hyperactivity
  • SB 206553
  • Serotonin

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health


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