TY - JOUR
T1 - Effects of omega-3 on behavioral and biochemical parameters in rats submitted to chronic mild stress
AU - de Mello, Aline H.aas
AU - Gassenferth, Aline
AU - Schraiber, Rosiane de Bona
AU - Souza, Luana da Rosa
AU - Florentino, Drielly
AU - Danielski, Lucinéia Gainski
AU - Cittadin-Soares, Evandro da Cruz
AU - Fortunato, Jucélia Jeremias
AU - Petronilho, Fabricia
AU - Quevedo, João
AU - Rezin, Gislaine T.ezza
N1 - Funding Information:
This research was supported by the Foundation for the Support of Scientific and Technological Research of Santa Catarina State (FAPESC) and the University of Southern Santa Catarina (UNISUL).
PY - 2014/9/1
Y1 - 2014/9/1
N2 - Major depression is a heterogeneous psychiatric disorder whose pathophysiology is not clearly established yet. Some studies have shown that oxidative stress and mitochondrial dysfunction are involved in the development of major depression. Since most depressed patients do not achieve complete remission of symptoms, new therapeutic alternatives are needed and omega-3 has been highlighted in this scenario. Therefore, we have investigated the effects of omega-3 on behavioral and biochemical parameters in rats submitted to chronic mild stress (CMS). Male Wistar rats were submitted to CMS for 40 days. After the CMS period, we administered a 500 mg/kg dose of omega-3 orally, once a day, for 7 days. The animals submitted to CMS presented anhedonia, had no significant weight gain, presented increased levels of lipid peroxidation and protein carbonylation, and inhibition of complex I and IV activities of the mitochondrial respiratory chain. The treatment with omega-3 did not reverse anhedonia; however, it reversed weight change, increased lipid peroxidation and protein carbonylation levels, and partially reversed the inhibition of mitochondrial respiratory chain complexes. The findings support studies that state that major depression is associated with mitochondrial dysfunction and oxidative stress, and that omega-3 supplementation could reverse some of these changes, probably due to its antioxidant properties.
AB - Major depression is a heterogeneous psychiatric disorder whose pathophysiology is not clearly established yet. Some studies have shown that oxidative stress and mitochondrial dysfunction are involved in the development of major depression. Since most depressed patients do not achieve complete remission of symptoms, new therapeutic alternatives are needed and omega-3 has been highlighted in this scenario. Therefore, we have investigated the effects of omega-3 on behavioral and biochemical parameters in rats submitted to chronic mild stress (CMS). Male Wistar rats were submitted to CMS for 40 days. After the CMS period, we administered a 500 mg/kg dose of omega-3 orally, once a day, for 7 days. The animals submitted to CMS presented anhedonia, had no significant weight gain, presented increased levels of lipid peroxidation and protein carbonylation, and inhibition of complex I and IV activities of the mitochondrial respiratory chain. The treatment with omega-3 did not reverse anhedonia; however, it reversed weight change, increased lipid peroxidation and protein carbonylation levels, and partially reversed the inhibition of mitochondrial respiratory chain complexes. The findings support studies that state that major depression is associated with mitochondrial dysfunction and oxidative stress, and that omega-3 supplementation could reverse some of these changes, probably due to its antioxidant properties.
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U2 - 10.1007/s11011-014-9577-5
DO - 10.1007/s11011-014-9577-5
M3 - Article
C2 - 24964972
AN - SCOPUS:85027926838
SN - 0885-7490
VL - 29
SP - 691
EP - 699
JO - Metabolic brain disease
JF - Metabolic brain disease
IS - 3
ER -