TY - JOUR
T1 - Effects of flagellin on the functions of follicle-associated epithelium
AU - Chabot, Sophie M.
AU - Shawi, May
AU - Eaves-Pyles, Tonyia
AU - Neutra, Marian R.
N1 - Funding Information:
Received 10 August 2007; accepted 6 November 2007; electronically published 22 August 2008. Potential conflicts of interest: none reported. Financial support: Canadian Institute of Health Research (postdoctoral fellowship to S.M.C.); National Institutes of Health (grant HD17557 to M.R.N.; grant DK34854 to the Harvard Digestive Diseases Center). Reprints or correspondence: Dr. Marian R. Neutra, Children’s Hospital, GI Cell Biology Laboratory, Enders 720, 300 Longwood Ave., Boston, MA 02115 ([email protected]).
PY - 2008/9/15
Y1 - 2008/9/15
N2 - Bacterial flagellin activates innate immune responses by signaling through Toll-like receptor 5 and is a potential vaccine adjuvant. Mucosal lymphoid follicles, inductive sites for adaptive mucosal immune responses, are covered by a follicle-associated epithelium (FAE) specialized for the uptake of antigens. This study demonstrates that mucosal application of Salmonella dublin flagellin enhanced transepithelial transport of microparticles by the FAE of mouse Peyer's patches in vivo. Flagellin also induced rapid, matrix metalloproteinase- dependent migration of subepithelial dendritic cells (DCs) into the FAE, better positioning DCs for antigen capture. These innate responses to flagellin enhance FAE functions and may promote adaptive immune responses in the mucosa.
AB - Bacterial flagellin activates innate immune responses by signaling through Toll-like receptor 5 and is a potential vaccine adjuvant. Mucosal lymphoid follicles, inductive sites for adaptive mucosal immune responses, are covered by a follicle-associated epithelium (FAE) specialized for the uptake of antigens. This study demonstrates that mucosal application of Salmonella dublin flagellin enhanced transepithelial transport of microparticles by the FAE of mouse Peyer's patches in vivo. Flagellin also induced rapid, matrix metalloproteinase- dependent migration of subepithelial dendritic cells (DCs) into the FAE, better positioning DCs for antigen capture. These innate responses to flagellin enhance FAE functions and may promote adaptive immune responses in the mucosa.
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U2 - 10.1086/591056
DO - 10.1086/591056
M3 - Article
C2 - 18721059
AN - SCOPUS:51749111427
SN - 0022-1899
VL - 198
SP - 907
EP - 910
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 6
ER -