Effects of enflurane and isoflurane on hepatic and renal circulations in chronically instrumented dogs

J. M. Bernard, M. F. Doursout, P. Wouters, C. J. Hartley, M. Cohen, R. G. Merin, J. E. Chelly

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Seven dogs were chronically instrumented for measurements of mean aortic blood pressure and cardiac output and for simultaneous measurements of hepatic, portal, and renal blood flows. Each animal was studied on two separate occasions, awake and during 1.2, 1.4, 1.75, and 2.0 MAC isoflurane and enflurane. Both anesthetics induced tachycardia; to a greater degree than isoflurane, enflurane lowered mean aortic blood pressure in a dose-dependent manner (-37, -45, -48, and -62% vs -19, -25, -41, and -44%, respectively) and cardiac output (-20, -26, -41, and -48% vs. -3, -5, -11, and -15%, respectively). With isoflurane, cardiac output decrease only at 1.75 and 2.0 MAC, and portal blood flow did not change significantly, whereas hepatic arterial blood flow increased at 1.75 and 2 MAC (by 28 and 33%, respectively). With enflurane, no significant changes were recorded in hepatic arterial blood flow, whereas portal blood flow decreased in a dose-dependent manner. Except at 2 MAC, hepatic circulation did not differ between anesthetics. Likewise, neither anesthetic significantly changed renal blood flow, except for enflurane at 2.0 MAC, which was associated with a 35% reduction. Both anesthetics led to similar systemic, hepatic, and renal vasodilations. Our data suggest that high concentrations of enflurane are associated with decreases in portal, total hepatic, and renal blood flow, most likely as a result of an anesthetic-induced cardiac depression.

Original languageEnglish (US)
Pages (from-to)298-302
Number of pages5
Issue number2
StatePublished - 1991
Externally publishedYes


  • Anesthetics, violatile: enflurane; isoflurane
  • Kidney: blood flow
  • Liver: blood flow

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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