Effects of calcium channel blockade on calcium homeostasis in mild to moderate essential hypertension

R. Townsend, D. J. Dipette, R. R. Evans, W. R. Davis, A. Green, G. A. Graham, J. M. Wallace, O. B. Holland

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Calcium channel blockers may alter parathyroid hormone secretion in vitro, which would alter calcium homeostasis. To determine the chronic effect of calcium channel blockade in vivo, we conducted a randomized, double blind, 16 week study comparing the effects of two pharmacologic antihypertensive agents, the calcium channel blocker diltiazem and the angiotensin-converting enzyme inhibitor captopril on parameters of calcium homeostasis. Both diltiazem and captopril lowered blood pressure to a similar degree. Neither drug produced any significant change in blood levels of total and ionized calcium, magnesium, or phosphorus, which affect the regulation of parathyroid hormone and vitamin D. In addition, at eight or 16 weeks following initiation, neither drug altered the serum levels of parathyroid hormone (PTH) or 1,25-(OH)2-vitamin D3 (1,25-D). Chronic calcium channel blockade with diltiazem does not alter serum parameters of calcium homeostasis and, thus, should not affect bone mineralization.

Original languageEnglish (US)
Pages (from-to)133-137
Number of pages5
JournalAmerican Journal of the Medical Sciences
Issue number3
StatePublished - 1990


  • Calcium channel blockers
  • Captopril
  • Diltiazem
  • Parathyroid hormone Vitamin D

ASJC Scopus subject areas

  • General Medicine


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