Effects of Anti-Thymocyte Serum on Lymphocytic Choriomeningitis (LCM) Virus Infection in Mice

M. S. Hirsch; F. A. Murphy; H. P. Russe; M. D. Hicklin

doi:10.3181/00379727-125-32254

Effects of Anti-Thymocyte Serum on Lymphocytic Choriomeningitis (LCM) Virus Infection in Mice

M. S. Hirsch, F. A. Murphy, H. P. Russe, M. D. Hicklin

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Rabbit anti-mouse thymocyte serum significantly modified the course of mouse LCM virus infection. Clinical and histologic signs of infection were absent so long as therapy was regularly maintained, and the severity of the host response to the virus was reduced following discontinuation of prolonged therapy. Treatment in the early period of incubation was more protective than at later times.

Original language	English (US)
Pages (from-to)	980-983
Number of pages	4
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	125
Issue number	3
DOIs	https://doi.org/10.3181/00379727-125-32254
State	Published - Jul 1967
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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title = "Effects of Anti-Thymocyte Serum on Lymphocytic Choriomeningitis (LCM) Virus Infection in Mice",

abstract = "Rabbit anti-mouse thymocyte serum significantly modified the course of mouse LCM virus infection. Clinical and histologic signs of infection were absent so long as therapy was regularly maintained, and the severity of the host response to the virus was reduced following discontinuation of prolonged therapy. Treatment in the early period of incubation was more protective than at later times.",

author = "Hirsch, {M. S.} and Murphy, {F. A.} and Russe, {H. P.} and Hicklin, {M. D.}",

note = "Funding Information: Hirsch M. S. Murphy F. A. Russe H. P. Hicklin M. D. U.S. Department of Health, Education and Welfare, Public Health Service, Bureau of Disease Prevention and Environmental Control, National Communicable Disease Center, Atlanta, Ga., and Department of Medicine, University of Chicago Clinics and Hospitals, Chicago, Ill. 7 1967 125 3 980 983 ",

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T1 - Effects of Anti-Thymocyte Serum on Lymphocytic Choriomeningitis (LCM) Virus Infection in Mice

AU - Hirsch, M. S.

AU - Murphy, F. A.

AU - Russe, H. P.

AU - Hicklin, M. D.

N1 - Funding Information: Hirsch M. S. Murphy F. A. Russe H. P. Hicklin M. D. U.S. Department of Health, Education and Welfare, Public Health Service, Bureau of Disease Prevention and Environmental Control, National Communicable Disease Center, Atlanta, Ga., and Department of Medicine, University of Chicago Clinics and Hospitals, Chicago, Ill. 7 1967 125 3 980 983

PY - 1967/7

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N2 - Rabbit anti-mouse thymocyte serum significantly modified the course of mouse LCM virus infection. Clinical and histologic signs of infection were absent so long as therapy was regularly maintained, and the severity of the host response to the virus was reduced following discontinuation of prolonged therapy. Treatment in the early period of incubation was more protective than at later times.

AB - Rabbit anti-mouse thymocyte serum significantly modified the course of mouse LCM virus infection. Clinical and histologic signs of infection were absent so long as therapy was regularly maintained, and the severity of the host response to the virus was reduced following discontinuation of prolonged therapy. Treatment in the early period of incubation was more protective than at later times.

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Effects of Anti-Thymocyte Serum on Lymphocytic Choriomeningitis (LCM) Virus Infection in Mice

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