Effector and regulatory roles for B cells in HIV infection?

Basile Siewe, Alan Landay

Research output: Contribution to journalArticlepeer-review


Toll-like receptor (TLR) signaling has been implicated in the genesis of HIV driven chronic immune activation and inflammation. In other inflammatory diseases, TLR driven B cell regulatory functions have been described, yet in HIV pathogenesis the focus has been on an antibody-dependent role for B cells. In this review, we discuss possible effector and regulatory functions exerted by (TLR) activated B cells during HIV infection.

Original languageEnglish (US)
Pages (from-to)348-352
Number of pages5
Issue number5
StatePublished - Aug 2012
Externally publishedYes


  • Chemokines
  • Chronic Immune Activation
  • IL-10
  • Immune Exhaustion
  • Microbial Translocation
  • Proinflammatory Cytokines
  • Regulatory B cells
  • Toll-like Receptor

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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