Effect of specific antibodies on chronic echovirus type 5 encephalitis in a patient with hypogammaglobulinemia

L. S. Weiner; J. T. Howell; M. P. Langford; G. J. Stanton; S. Baron; R. M. Goldblum; R. A. Lord; A. S. Goldman

doi:10.1093/infdis/140.6.858

Effect of specific antibodies on chronic echovirus type 5 encephalitis in a patient with hypogammaglobulinemia

L. S. Weiner, J. T. Howell, M. P. Langford, G. J. Stanton, S. Baron, R. M. Goldblum, R. A. Lord, A. S. Goldman

Pediatrics

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Abstract

The effects of specific antibodies in chronic echovirus type 5 (echo 5) encephalitis were investigated in a patient with x-linked hypogammaglobulinemia. Virus was detected in cerebrospinal fluid (CSF) and blood despite treatment with commercial human gammaglobulin that contained low titers of antibodies to echo 5 (0.6 × 10⁴ units per injection). Virus disappeared from blood and CSF when plasma containing high concentrations of antibodies (total dose, 1-4 × 10⁴ units/kg) was administered intravenously. Maximal inhibition of virus was achieved in culture and in the patient’s CSF when the titer of antibody to echo 5 in CSF was ≥ 16 units/ml. Although the patient died, hyperimmune plasma improved the neurologic status and eliminated detectable virus from the blood and CSF.

Original language	English (US)
Pages (from-to)	858-863
Number of pages	6
Journal	Journal of Infectious Diseases
Volume	140
Issue number	6
DOIs	https://doi.org/10.1093/infdis/140.6.858
State	Published - Dec 1979

ASJC Scopus subject areas

General Medicine

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@article{eb9de2866447401fbc51cd8da93b357a,

title = "Effect of specific antibodies on chronic echovirus type 5 encephalitis in a patient with hypogammaglobulinemia",

abstract = "The effects of specific antibodies in chronic echovirus type 5 (echo 5) encephalitis were investigated in a patient with x-linked hypogammaglobulinemia. Virus was detected in cerebrospinal fluid (CSF) and blood despite treatment with commercial human gammaglobulin that contained low titers of antibodies to echo 5 (0.6 × 104 units per injection). Virus disappeared from blood and CSF when plasma containing high concentrations of antibodies (total dose, 1-4 × 104 units/kg) was administered intravenously. Maximal inhibition of virus was achieved in culture and in the patient{\textquoteright}s CSF when the titer of antibody to echo 5 in CSF was ≥ 16 units/ml. Although the patient died, hyperimmune plasma improved the neurologic status and eliminated detectable virus from the blood and CSF.",

author = "Weiner, {L. S.} and Howell, {J. T.} and Langford, {M. P.} and Stanton, {G. J.} and S. Baron and Goldblum, {R. M.} and Lord, {R. A.} and Goldman, {A. S.}",

note = "Funding Information: This work was supported in part by James W. McLaughlin Postdoctoral Fellowships awarded to L. S. Weiner and J. T. Howell; by a James W. McLaughlin Predoctoral Fellowship awarded to M. P. Langford; by research grant no. DHEW RR-00073-14 from the General Clinical Research Centers Branch, Division of Research Facilities and Resources, National Institutes of Health; and by Public Health Research grant no. EY 01715-03 from the National Eye Institute.",

year = "1979",

month = dec,

doi = "10.1093/infdis/140.6.858",

language = "English (US)",

volume = "140",

pages = "858--863",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "6",

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T1 - Effect of specific antibodies on chronic echovirus type 5 encephalitis in a patient with hypogammaglobulinemia

AU - Weiner, L. S.

AU - Howell, J. T.

AU - Langford, M. P.

AU - Stanton, G. J.

AU - Baron, S.

AU - Goldblum, R. M.

AU - Lord, R. A.

AU - Goldman, A. S.

N1 - Funding Information: This work was supported in part by James W. McLaughlin Postdoctoral Fellowships awarded to L. S. Weiner and J. T. Howell; by a James W. McLaughlin Predoctoral Fellowship awarded to M. P. Langford; by research grant no. DHEW RR-00073-14 from the General Clinical Research Centers Branch, Division of Research Facilities and Resources, National Institutes of Health; and by Public Health Research grant no. EY 01715-03 from the National Eye Institute.

PY - 1979/12

Y1 - 1979/12

N2 - The effects of specific antibodies in chronic echovirus type 5 (echo 5) encephalitis were investigated in a patient with x-linked hypogammaglobulinemia. Virus was detected in cerebrospinal fluid (CSF) and blood despite treatment with commercial human gammaglobulin that contained low titers of antibodies to echo 5 (0.6 × 104 units per injection). Virus disappeared from blood and CSF when plasma containing high concentrations of antibodies (total dose, 1-4 × 104 units/kg) was administered intravenously. Maximal inhibition of virus was achieved in culture and in the patient’s CSF when the titer of antibody to echo 5 in CSF was ≥ 16 units/ml. Although the patient died, hyperimmune plasma improved the neurologic status and eliminated detectable virus from the blood and CSF.

AB - The effects of specific antibodies in chronic echovirus type 5 (echo 5) encephalitis were investigated in a patient with x-linked hypogammaglobulinemia. Virus was detected in cerebrospinal fluid (CSF) and blood despite treatment with commercial human gammaglobulin that contained low titers of antibodies to echo 5 (0.6 × 104 units per injection). Virus disappeared from blood and CSF when plasma containing high concentrations of antibodies (total dose, 1-4 × 104 units/kg) was administered intravenously. Maximal inhibition of virus was achieved in culture and in the patient’s CSF when the titer of antibody to echo 5 in CSF was ≥ 16 units/ml. Although the patient died, hyperimmune plasma improved the neurologic status and eliminated detectable virus from the blood and CSF.

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Effect of specific antibodies on chronic echovirus type 5 encephalitis in a patient with hypogammaglobulinemia

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