Effect of pinealectomy, binding, castration and melatonin on nerve growth factor levels in the submaxillary glands of mice

J. R. Perez-Polo; K. Hall; M. K. Vaughan; R. J. Reiter

doi:10.1016/0304-3940(78)90016-2

Effect of pinealectomy, binding, castration and melatonin on nerve growth factor levels in the submaxillary glands of mice

J. R. Perez-Polo, K. Hall, M. K. Vaughan, R. J. Reiter

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Abstract

The effects of blinding alone or in combination with pinealectomy, castration and melatonin treatment on nerve growth factor (NGF) in submaxillary glands of mice were tested. Both pinealectomy and melatonin (placed subcutaneously in beeswax) treatment caused a marked reduction in NGF specific biological activity, esterase activity, and β-protein recovered from the submaxillary glands. Castrated mice also exhibited depressed levels of NGF in the salivary glands.

Original language	English (US)
Pages (from-to)	83-87
Number of pages	5
Journal	Neuroscience Letters
Volume	10
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3940(78)90016-2
State	Published - Nov 1978
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(78)90016-2

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abstract = "The effects of blinding alone or in combination with pinealectomy, castration and melatonin treatment on nerve growth factor (NGF) in submaxillary glands of mice were tested. Both pinealectomy and melatonin (placed subcutaneously in beeswax) treatment caused a marked reduction in NGF specific biological activity, esterase activity, and β-protein recovered from the submaxillary glands. Castrated mice also exhibited depressed levels of NGF in the salivary glands.",

author = "Perez-Polo, {J. R.} and K. Hall and Vaughan, {M. K.} and Reiter, {R. J.}",

year = "1978",

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AU - Perez-Polo, J. R.

AU - Hall, K.

AU - Vaughan, M. K.

AU - Reiter, R. J.

PY - 1978/11

Y1 - 1978/11

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AB - The effects of blinding alone or in combination with pinealectomy, castration and melatonin treatment on nerve growth factor (NGF) in submaxillary glands of mice were tested. Both pinealectomy and melatonin (placed subcutaneously in beeswax) treatment caused a marked reduction in NGF specific biological activity, esterase activity, and β-protein recovered from the submaxillary glands. Castrated mice also exhibited depressed levels of NGF in the salivary glands.

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Effect of pinealectomy, binding, castration and melatonin on nerve growth factor levels in the submaxillary glands of mice

Abstract

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