Effect of NMSO3 treatment in a murine model of human metapneumovirus infection

Leanne Spetch; Terry L. Bowlin; Antonella Casola

doi:10.1099/vir.0.2008/003301-0

Effect of NMSO3 treatment in a murine model of human metapneumovirus infection

Leanne Spetch, Terry L. Bowlin, Antonella Casola

Pediatrics

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Abstract

BALB/c mice infected with human metapneumovirus (hMPV) were treated with the sulfated sialyl lipid NMSO3 (one dose of 50 mg kg^-1) given at the time of infection. NMSO3 significantly reduced viral replication in the lungs, as well as hMPV-induced body weight loss, pulmonary inflammation and cytokine production, suggesting that antiviral treatment initiated at the beginning of viral infection can modify hMPV-induced disease.

Original language	English (US)
Pages (from-to)	2709-2712
Number of pages	4
Journal	Journal of General Virology
Volume	89
Issue number	11
DOIs	https://doi.org/10.1099/vir.0.2008/003301-0
State	Published - 2008

ASJC Scopus subject areas

Virology

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10.1099/vir.0.2008/003301-0

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abstract = "BALB/c mice infected with human metapneumovirus (hMPV) were treated with the sulfated sialyl lipid NMSO3 (one dose of 50 mg kg-1) given at the time of infection. NMSO3 significantly reduced viral replication in the lungs, as well as hMPV-induced body weight loss, pulmonary inflammation and cytokine production, suggesting that antiviral treatment initiated at the beginning of viral infection can modify hMPV-induced disease.",

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AB - BALB/c mice infected with human metapneumovirus (hMPV) were treated with the sulfated sialyl lipid NMSO3 (one dose of 50 mg kg-1) given at the time of infection. NMSO3 significantly reduced viral replication in the lungs, as well as hMPV-induced body weight loss, pulmonary inflammation and cytokine production, suggesting that antiviral treatment initiated at the beginning of viral infection can modify hMPV-induced disease.

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Effect of NMSO3 treatment in a murine model of human metapneumovirus infection

Abstract

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