Effect of long-term L-dopa administration on striatal extracellular dopamine release

Timothy Brannan; Julian Martinez-Tica; Melvin D. Yahr

doi:10.1212/wnl.41.4.596

Effect of long-term L-dopa administration on striatal extracellular dopamine release

Timothy Brannan, Julian Martinez-Tica, Melvin D. Yahr

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

When L-dopa was administered acutely to rats, the increase in the extracellular level of dopamine in the corpus striatum was attenuated by 43% in animals that had received L-dopa daily for 60 days as compared with animals receiving placebo. These findings indicate that chronic treatment with L-dopa impairs striatal dopamine formation or release.

Original language	English (US)
Pages (from-to)	596-598
Number of pages	3
Journal	Neurology
Volume	41
Issue number	4
DOIs	https://doi.org/10.1212/wnl.41.4.596
State	Published - Apr 1991
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology

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10.1212/wnl.41.4.596

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title = "Effect of long-term L-dopa administration on striatal extracellular dopamine release",

abstract = "When L-dopa was administered acutely to rats, the increase in the extracellular level of dopamine in the corpus striatum was attenuated by 43% in animals that had received L-dopa daily for 60 days as compared with animals receiving placebo. These findings indicate that chronic treatment with L-dopa impairs striatal dopamine formation or release.",

author = "Timothy Brannan and Julian Martinez-Tica and Yahr, {Melvin D.}",

year = "1991",

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AU - Yahr, Melvin D.

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AB - When L-dopa was administered acutely to rats, the increase in the extracellular level of dopamine in the corpus striatum was attenuated by 43% in animals that had received L-dopa daily for 60 days as compared with animals receiving placebo. These findings indicate that chronic treatment with L-dopa impairs striatal dopamine formation or release.

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Effect of long-term L-dopa administration on striatal extracellular dopamine release

Abstract

ASJC Scopus subject areas

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