Effect of ibuprofen on thermal injury with smoke inhalation

Ibuprofen inhibits cyclooxygenase as well as the activity of neutrophils. We determined the effect of ibuprofen on the pathophysiological changes which occur after burn and smoke inhalation. Five-day after surgical preparation, 12 sheep underwent a 40% 3° burn, given 48 breaths of cotton smoke, were mechanically ventilated for the next 24 hrs in the awake state and resuscitated with Ringer's solution. One hour after injury, they were randomized into 2 groups. The Control group (n=6) was given lactated Riger's solution alone and ibuprofen group (n=6) was given a 12 mg/kg bolus injection and 6 mg/kg/hr a continuous venous infusion of ibuprofen with lactated Ringer's solution. There was an increase in lung lymph flow and reduced PaO₂ in the Control group. Ibuprofen attenuated the decrease in P/F ratio, but not the edema. Plasma nitrite/nitrate was increased in the Control group but not in the ibuprofen group suggesting that that ibuprofen has beneficial and detrimental actions. (Values are mean ± SEM, *=P<0.05) variable group baseline 6 hr 96hr P/F ratio Control 481 ± 20 472 ± 51 168 ± 65*(mmHg) Ibuprofen 451 ± 12 429 ± 63 222 ± 48*Lymph Flow Control 4.7 ± 0.4 10.8 ± 3.2 17.5 ± 8.5*(ml/min) Ibuprofen 6.3 ± 1.0 17.5 ± 5.2 30.0 ± 8.5*nitrite/nitrate Control 8.4 ± 2.2 15.7 ± 2.3 23.0 ± 5.0*(μM) Ibuprofen 9.1 ± 2.5 11.6 ± 3.3 1 8.2 ± 4.6 1.