Effect of coagulation on laser light distribution in myocardial tissue

Ramtin Agah, Devang Sheth, Massoud Motamedi

Research output: Contribution to journalConference articlepeer-review

2 Scopus citations


The changes in total reflection and transmission of porcine myocardium due to thermal coagulation were measured during tissue heating in a temperature-controlled water bath, at different temperature ranging between 54°-63°C. At 633 nm, the measurements yield a picture of continuous decrease in transmission and a peak with a subsequent fall (approximately 10% from the peak) in reflection measurements of the tissue during coagulation process. Utilizing these measurements and an inverse solution to the radiative transfer equation, the optical properties of tissue, absorption, μa, and effective scattering, μ′s= μs(l-g) were calculated. A one-dimensional diffusion approximation was used to demonstrate the effects of thermally induced changes in the optical properties of tissue on light distribution in tissue. The pattern of changes in μa and μ′s seen to indicate that several simultaneous rate processes may be responsible for tissue coagulation. A postulate is put forward to use one such rate process to characterize threshold thermal damage to porcine myocardium and the accompanying protein denaturation.

Original languageEnglish (US)
Pages (from-to)172-179
Number of pages8
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 1991
Externally publishedYes
EventProceedings of Diagnostic and Therapeutic Cardiovascular Interventions - Los Angeles, CA, USA
Duration: Jan 20 1991Jan 22 1991

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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