Effect of bromide on evoked release of monoamines from brain slices and intact atria

James S. Goodwin; Richard I. Katz; Irwin J. Kopin

doi:10.1038/221556a0

Effect of bromide on evoked release of monoamines from brain slices and intact atria

James S. Goodwin, Richard I. Katz, Irwin J. Kopin

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Abstract

Many "psychoactive" drugs seem to influence monoamine metabolism in experimental animals. Such drugs have been suggested to act through their effects on monoamines in the central nervous system¹. Bromide is a well known sedative although its mode of action remains uncertain. It has been suggested that the bromide ion interferes with synaptic transmission at cholinergic terminals², but this has been disputed³. We have investigated the effect of bromide ions on release of other putative neurotransmitters - noradrenaline, serotonin and γ-aminobutyric acid.

Original language	English (US)
Pages (from-to)	556-557
Number of pages	2
Journal	Nature
Volume	221
Issue number	5180
DOIs	https://doi.org/10.1038/221556a0
State	Published - 1969
Externally published	Yes

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title = "Effect of bromide on evoked release of monoamines from brain slices and intact atria",

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author = "Goodwin, {James S.} and Katz, {Richard I.} and Kopin, {Irwin J.}",

year = "1969",

doi = "10.1038/221556a0",

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T1 - Effect of bromide on evoked release of monoamines from brain slices and intact atria

AU - Goodwin, James S.

AU - Katz, Richard I.

AU - Kopin, Irwin J.

PY - 1969

Y1 - 1969

N2 - Many "psychoactive" drugs seem to influence monoamine metabolism in experimental animals. Such drugs have been suggested to act through their effects on monoamines in the central nervous system1. Bromide is a well known sedative although its mode of action remains uncertain. It has been suggested that the bromide ion interferes with synaptic transmission at cholinergic terminals2, but this has been disputed3. We have investigated the effect of bromide ions on release of other putative neurotransmitters - noradrenaline, serotonin and γ-aminobutyric acid.

AB - Many "psychoactive" drugs seem to influence monoamine metabolism in experimental animals. Such drugs have been suggested to act through their effects on monoamines in the central nervous system1. Bromide is a well known sedative although its mode of action remains uncertain. It has been suggested that the bromide ion interferes with synaptic transmission at cholinergic terminals2, but this has been disputed3. We have investigated the effect of bromide ions on release of other putative neurotransmitters - noradrenaline, serotonin and γ-aminobutyric acid.

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ER -

Effect of bromide on evoked release of monoamines from brain slices and intact atria

Abstract

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