Effect of alpha-interferon on erythrocyte and hepatocyte plasma membranes derived from cirrhotic rats

Pablo Muriel; Javier Bolaños; Jose M. Barral; Gustavo Torres

doi:10.1159/000139163

Effect of alpha-interferon on erythrocyte and hepatocyte plasma membranes derived from cirrhotic rats

Pablo Muriel, Javier Bolaños, Jose M. Barral, Gustavo Torres

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Interferons are recognized to inhibit collagen production. Since fibrosis has been associated with liver dysfunction, we investigated the effects of α-interferon on the function and lipid composition of hepatocyte and erythrocyte plasma membranes derived from CCLl-cirrhotic male Wistar rats. In both cell types, CCl₄ decreased Na⁺/K⁺ and Ca²⁺-ATPase activity and increased the cholesterol to phospholipids (CH/PL) ratio (p < 0.05). Administration of interferon (80, 000 IU/kg s.c. for 8 weeks) increased survival from 40 to 90%, and preserved normal ATPase activity and CH/PL ratio. Our results show that administration of α-interferon to CCl₄-cirrhotic rats improves survival, and liver and erythrocyte membrane function and composition, probably as a result of its antifibrogenic effect.

Original language	English (US)
Pages (from-to)	63-68
Number of pages	6
Journal	Pharmacology
Volume	48
Issue number	1
DOIs	https://doi.org/10.1159/000139163
State	Published - 1994
Externally published	Yes

Keywords

ATPases
Carbon tetrachloride
Cirrhosis
Erythrocytes
Lipids
Liver injury
Wistar rats

ASJC Scopus subject areas

Pharmacology

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10.1159/000139163

Cite this

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title = "Effect of alpha-interferon on erythrocyte and hepatocyte plasma membranes derived from cirrhotic rats",

abstract = "Interferons are recognized to inhibit collagen production. Since fibrosis has been associated with liver dysfunction, we investigated the effects of α-interferon on the function and lipid composition of hepatocyte and erythrocyte plasma membranes derived from CCLl-cirrhotic male Wistar rats. In both cell types, CCl4 decreased Na+/K+ and Ca2+-ATPase activity and increased the cholesterol to phospholipids (CH/PL) ratio (p < 0.05). Administration of interferon (80, 000 IU/kg s.c. for 8 weeks) increased survival from 40 to 90%, and preserved normal ATPase activity and CH/PL ratio. Our results show that administration of α-interferon to CCl4-cirrhotic rats improves survival, and liver and erythrocyte membrane function and composition, probably as a result of its antifibrogenic effect.",

keywords = "ATPases, Carbon tetrachloride, Cirrhosis, Erythrocytes, Lipids, Liver injury, Wistar rats",

author = "Pablo Muriel and Javier Bola{\~n}os and Barral, {Jose M.} and Gustavo Torres",

year = "1994",

doi = "10.1159/000139163",

language = "English (US)",

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pages = "63--68",

journal = "Pharmacology",

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T1 - Effect of alpha-interferon on erythrocyte and hepatocyte plasma membranes derived from cirrhotic rats

AU - Muriel, Pablo

AU - Bolaños, Javier

AU - Barral, Jose M.

AU - Torres, Gustavo

PY - 1994

Y1 - 1994

N2 - Interferons are recognized to inhibit collagen production. Since fibrosis has been associated with liver dysfunction, we investigated the effects of α-interferon on the function and lipid composition of hepatocyte and erythrocyte plasma membranes derived from CCLl-cirrhotic male Wistar rats. In both cell types, CCl4 decreased Na+/K+ and Ca2+-ATPase activity and increased the cholesterol to phospholipids (CH/PL) ratio (p < 0.05). Administration of interferon (80, 000 IU/kg s.c. for 8 weeks) increased survival from 40 to 90%, and preserved normal ATPase activity and CH/PL ratio. Our results show that administration of α-interferon to CCl4-cirrhotic rats improves survival, and liver and erythrocyte membrane function and composition, probably as a result of its antifibrogenic effect.

AB - Interferons are recognized to inhibit collagen production. Since fibrosis has been associated with liver dysfunction, we investigated the effects of α-interferon on the function and lipid composition of hepatocyte and erythrocyte plasma membranes derived from CCLl-cirrhotic male Wistar rats. In both cell types, CCl4 decreased Na+/K+ and Ca2+-ATPase activity and increased the cholesterol to phospholipids (CH/PL) ratio (p < 0.05). Administration of interferon (80, 000 IU/kg s.c. for 8 weeks) increased survival from 40 to 90%, and preserved normal ATPase activity and CH/PL ratio. Our results show that administration of α-interferon to CCl4-cirrhotic rats improves survival, and liver and erythrocyte membrane function and composition, probably as a result of its antifibrogenic effect.

KW - ATPases

KW - Carbon tetrachloride

KW - Cirrhosis

KW - Erythrocytes

KW - Lipids

KW - Liver injury

KW - Wistar rats

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Effect of alpha-interferon on erythrocyte and hepatocyte plasma membranes derived from cirrhotic rats

Abstract

Keywords

ASJC Scopus subject areas

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