TY - JOUR
T1 - Effect of Acute Negative and Positive Energy Balance on Basal Very-Low Density Lipoprotein Triglyceride Metabolism in Women
AU - Bellou, Elena
AU - Maraki, Maria
AU - Magkos, Faidon
AU - Botonaki, Helena
AU - Panagiotakos, Demosthenes B.
AU - Kavouras, Stavros A.
AU - Sidossis, Labros S.
PY - 2013/3/22
Y1 - 2013/3/22
N2 - Background: Acute reduction in dietary energy intake reduces very low-density lipoprotein triglyceride (VLDL-TG) concentration. Although chronic dietary energy surplus and obesity are associated with hypertriglyceridemia, the effect of acute overfeeding on VLDL-TG metabolism is not known. Objective: The aim of the present study was to investigate the effects of acute negative and positive energy balance on VLDL-TG metabolism in healthy women. Design: Ten healthy women (age: 22.0±2.9 years, BMI: 21.2±1.3 kg/m2) underwent a stable isotopically labeled tracer infusion study to determine basal VLDL-TG kinetics after performing, in random order, three experimental trials on the previous day: i) isocaloric feeding (control) ii) hypocaloric feeding with a dietary energy restriction of 2.89±0.42 MJ and iii) hypercaloric feeding with a dietary energy surplus of 2.91±0.32 MJ. The three diets had the same macronutrient composition. Results: Fasting plasma VLDL-TG concentrations decreased by ~26% after hypocaloric feeding relative to the control trial (P = 0.037), owing to decreased hepatic VLDL-TG secretion rate (by 21%, P = 0.023) and increased VLDL-TG plasma clearance rate (by ~12%, P = 0.016). Hypercaloric feeding increased plasma glucose concentration (P = 0.042) but had no effect on VLDL-TG concentration and kinetics compared to the control trial. Conclusion: Acute dietary energy deficit (~3MJ) leads to hypotriglyceridemia via a combination of decreased hepatic VLDL-TG secretion and increased VLDL-TG clearance. On the other hand, acute dietary energy surplus (~3MJ) does not affect basal VLDL-TG metabolism but disrupts glucose homeostasis in healthy women.
AB - Background: Acute reduction in dietary energy intake reduces very low-density lipoprotein triglyceride (VLDL-TG) concentration. Although chronic dietary energy surplus and obesity are associated with hypertriglyceridemia, the effect of acute overfeeding on VLDL-TG metabolism is not known. Objective: The aim of the present study was to investigate the effects of acute negative and positive energy balance on VLDL-TG metabolism in healthy women. Design: Ten healthy women (age: 22.0±2.9 years, BMI: 21.2±1.3 kg/m2) underwent a stable isotopically labeled tracer infusion study to determine basal VLDL-TG kinetics after performing, in random order, three experimental trials on the previous day: i) isocaloric feeding (control) ii) hypocaloric feeding with a dietary energy restriction of 2.89±0.42 MJ and iii) hypercaloric feeding with a dietary energy surplus of 2.91±0.32 MJ. The three diets had the same macronutrient composition. Results: Fasting plasma VLDL-TG concentrations decreased by ~26% after hypocaloric feeding relative to the control trial (P = 0.037), owing to decreased hepatic VLDL-TG secretion rate (by 21%, P = 0.023) and increased VLDL-TG plasma clearance rate (by ~12%, P = 0.016). Hypercaloric feeding increased plasma glucose concentration (P = 0.042) but had no effect on VLDL-TG concentration and kinetics compared to the control trial. Conclusion: Acute dietary energy deficit (~3MJ) leads to hypotriglyceridemia via a combination of decreased hepatic VLDL-TG secretion and increased VLDL-TG clearance. On the other hand, acute dietary energy surplus (~3MJ) does not affect basal VLDL-TG metabolism but disrupts glucose homeostasis in healthy women.
UR - http://www.scopus.com/inward/record.url?scp=84875355297&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875355297&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0060251
DO - 10.1371/journal.pone.0060251
M3 - Article
C2 - 23533676
AN - SCOPUS:84875355297
SN - 1932-6203
VL - 8
JO - PloS one
JF - PloS one
IS - 3
M1 - e60251
ER -