Effect of a bradykinin antagonist on the local inflammatory response following thermal injury

F. E. Nwariaku, P. J. Sikes, E. Lightfoot, W. J. Mileski, C. Baxter

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Partial and full thickness burns with intervening zones of stasis were created on the backs of New Zealand White rabbits (n = 23). Either saline or the bradykinin receptor antagonist, NPC 17731, was administered. Skin blood flow was measured hourly using a laser Doppler blood flowmeter. After 4h skin samples were harvested for assessment of tissue oedema (wet/dry weights) and leucocyte accumulation (immunohistochemistry). Statistical analysis was performed using Analysis of Variance (ANOVA) and Mann-Whitney U test with a level of significance at P < 0.005. It was found that blood flow was decreased postburn in all groups. Bradykinin antagonist resulted in increased blood flow in partial thickness burns and zones of stasis compared to saline-treated animals (P < 0.05). Pretreatment with bradykinin antagonist showed reduced tissue oedema in leucocyte burns (P < 0.05). No significant difference was observed in leucocyte accumulation between both groups. These data suggest a role for bradykinin in the pathogenesis of postburn microvascular changes which is independent of leucocyte-mediated injury.

Original languageEnglish (US)
Pages (from-to)324-327
Number of pages4
Issue number4
StatePublished - Jun 1996
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Emergency Medicine
  • Critical Care and Intensive Care Medicine


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