Effect of γ-aminobutyric acid on bombesin-evoked release of somatostatin and gastrin from isolated rat stomach

Yan Shi Guo; James C. Thompson; Pomila Singh

doi:10.1016/0167-0115(89)90236-X

Effect of γ-aminobutyric acid on bombesin-evoked release of somatostatin and gastrin from isolated rat stomach

Yan Shi Guo, James C. Thompson, Pomila Singh

Neuroscience & Cell

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The effect of γ-aminobutyric acid (GABA) on basal and bombesin (BBS)-stimulated release of somatostatin (SLI) and gastrin from isolated perfused rat stomach was examined. In the control study, BBS at a dose of 10 nM significantly stimulated release of SLI and gastrin. Infusion of GABA (1-1000 nM) caused a depression of SLI release induced by BBS (10 nM) in a dose-dependent fashion. However, at doses used in this study GABA had no effect on either basal level of SLI and gastrin or BBS-elicited gastrin release. These results indicate that GABA can specifically modulate BBS-induced SLI release from rat stomach.

Original language	English (US)
Pages (from-to)	179-186
Number of pages	8
Journal	Regulatory Peptides
Volume	24
Issue number	2
DOIs	https://doi.org/10.1016/0167-0115(89)90236-X
State	Published - Feb 1989

Keywords

Bombesin
Gastrin
Somatostatin
γ-aminobutyric acid

ASJC Scopus subject areas

Endocrinology
Cellular and Molecular Neuroscience
Physiology
Biochemistry
Clinical Biochemistry

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10.1016/0167-0115(89)90236-X

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title = "Effect of γ-aminobutyric acid on bombesin-evoked release of somatostatin and gastrin from isolated rat stomach",

abstract = "The effect of γ-aminobutyric acid (GABA) on basal and bombesin (BBS)-stimulated release of somatostatin (SLI) and gastrin from isolated perfused rat stomach was examined. In the control study, BBS at a dose of 10 nM significantly stimulated release of SLI and gastrin. Infusion of GABA (1-1000 nM) caused a depression of SLI release induced by BBS (10 nM) in a dose-dependent fashion. However, at doses used in this study GABA had no effect on either basal level of SLI and gastrin or BBS-elicited gastrin release. These results indicate that GABA can specifically modulate BBS-induced SLI release from rat stomach.",

keywords = "Bombesin, Gastrin, Somatostatin, γ-aminobutyric acid",

author = "Guo, {Yan Shi} and Thompson, {James C.} and Pomila Singh",

note = "Funding Information: We would like to thank Kay Smith for her assistance, in the preparation of this manuscript and Azar Owlia, Perry Orchard and Allen Spannagel for their technical assistance. Supported by grants from the National Institute of Health (RO1 DK 15241, PO1 DK 35608 and CA 38651).",

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AU - Guo, Yan Shi

AU - Thompson, James C.

AU - Singh, Pomila

N1 - Funding Information: We would like to thank Kay Smith for her assistance, in the preparation of this manuscript and Azar Owlia, Perry Orchard and Allen Spannagel for their technical assistance. Supported by grants from the National Institute of Health (RO1 DK 15241, PO1 DK 35608 and CA 38651).

PY - 1989/2

Y1 - 1989/2

N2 - The effect of γ-aminobutyric acid (GABA) on basal and bombesin (BBS)-stimulated release of somatostatin (SLI) and gastrin from isolated perfused rat stomach was examined. In the control study, BBS at a dose of 10 nM significantly stimulated release of SLI and gastrin. Infusion of GABA (1-1000 nM) caused a depression of SLI release induced by BBS (10 nM) in a dose-dependent fashion. However, at doses used in this study GABA had no effect on either basal level of SLI and gastrin or BBS-elicited gastrin release. These results indicate that GABA can specifically modulate BBS-induced SLI release from rat stomach.

AB - The effect of γ-aminobutyric acid (GABA) on basal and bombesin (BBS)-stimulated release of somatostatin (SLI) and gastrin from isolated perfused rat stomach was examined. In the control study, BBS at a dose of 10 nM significantly stimulated release of SLI and gastrin. Infusion of GABA (1-1000 nM) caused a depression of SLI release induced by BBS (10 nM) in a dose-dependent fashion. However, at doses used in this study GABA had no effect on either basal level of SLI and gastrin or BBS-elicited gastrin release. These results indicate that GABA can specifically modulate BBS-induced SLI release from rat stomach.

KW - Bombesin

KW - Gastrin

KW - Somatostatin

KW - γ-aminobutyric acid

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ER -

Effect of γ-aminobutyric acid on bombesin-evoked release of somatostatin and gastrin from isolated rat stomach

Abstract

Keywords

ASJC Scopus subject areas

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