Efetividade da vacina antiamarilica 17D: Uma avaliacao epidemiologica em servicos de saude

Translated title of the contribution: Efficacy of the 17D yellow fever vaccine: An epidemiologic evaluation in health services

Henrique Leonardo Guerra, Tânia Mara Sardinha, Amélia P.A.T. Da Rosa, Maria Fernanda Lima E Costa

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


The purpose of this study was to evaluate the efficacy of the 17D yellow fever vaccine in the conditions under which it is used in public health services. In 1989, a nonconcurrent prospective study was carried out in Bocaiuva, Minas Cerais State, Brazil, 6 months after mass vaccination of the population. The study population was made up of first-grade students from all the schools in Bocaiuva. The exposed group consisted of a simple random sample of vaccinated students (n = 173) and the unexposed group consisted of all those who had not been vaccinated (n = 55). Serum samples were examined with the neutralization test in mice; these tests were conducted blind, that is, the examiner did not know the vaccination status of the subject. The serology results were as follows: of those vaccinated, 75% were seropositive, 17% were seronegative, and 7% showed an inconclusive result; in the unvaccinated children, these results were 9%, 87%, and 4%, respectively. The age-adjusted seropositivity ratio between vaccinated and unvaccinated children was 7.6 (95% CI: 3.4 to 16.7). The proportion of seropositivity attributable to vaccination, adjusted for age, was 86.8% (95% CI: 70.6 to 94.0). The results showed that the efficacy of the vaccine, defined by means of seropositivity for the virus, was below the levels expected for the 17D vaccine. This may have been due to operational failures in the conservation or application of the vaccine. The results point to the need for routine systematic evaluations by the health services after mass utilization of the vaccine.

Translated title of the contributionEfficacy of the 17D yellow fever vaccine: An epidemiologic evaluation in health services
Original languagePortuguese
Pages (from-to)115-120
Number of pages6
JournalRevista Panamericana de Salud Publica/Pan American Journal of Public Health
Issue number2
StatePublished - 1997
Externally publishedYes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health


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