EBV-associated Kikuchi's histiocytic necrotizing lymphadenitis with cutaneous manifestations

A. Yen, P. Fearneyhough, S. S. Raimer, S. D. Hudnall

Research output: Contribution to journalArticlepeer-review

104 Scopus citations


The clinical and pathologic findings of Kikuchi's histiocytic necrotizing lymphadenitis may mimic those of malignant lymphoma. We describe a 6-year-old boy with generalized lymphadenopathy, spiking fever, chills, myalgias, malaise, and erythematous, crusted papules. Although cutaneous manifestations have been noted in 16% to 40% of patients with histiocytic necrotizing lymphadenitis, only three publications described skin lesions. The skin lesions and affected lymph nodes revealed histiocytic aggregates, atypical lymphoid cells, karyorrhectic debris, and patchy necrosis. Spontaneous resolution occurred in 2 months. Results of serologic studies, Epstein-Barr virus (EBV) latent membrane protein immunoperoxidase staining. EBER-1 RNA in-situ hybridization, and EBV EBNA-1 DNA polymerase chain reaction implicate EBV as the causative agent.

Original languageEnglish (US)
Pages (from-to)342-346
Number of pages5
JournalJournal of the American Academy of Dermatology
Issue number2 SUPPL.
StatePublished - 1997
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology


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