TY - JOUR
T1 - Ebolavirus Evolution
T2 - Past and Present
AU - de La Vega, Marc Antoine
AU - Stein, Derek
AU - Kobinger, Gary P.
N1 - Publisher Copyright:
© 2015 de La Vega et al.
PY - 2015/11/1
Y1 - 2015/11/1
N2 - The past year has marked the most devastating Ebola outbreak the world has ever witnessed, with over 28,000 cases and over 11,000 deaths. Ebola virus (EBOV) has now been around for almost 50 years. In this review, we discuss past and present outbreaks of EBOV and how those variants evolved over time. We explore and discuss selective pressures that drive the evolution of different Ebola variants, and how they may modify the efficacy of therapeutic treatments and vaccines currently being developed. Finally, given the unprecedented size and spread of the outbreak, as well as the extended period of replication in human hosts, specific attention is given to the 2014–2015 West African outbreak variant (Makona).
AB - The past year has marked the most devastating Ebola outbreak the world has ever witnessed, with over 28,000 cases and over 11,000 deaths. Ebola virus (EBOV) has now been around for almost 50 years. In this review, we discuss past and present outbreaks of EBOV and how those variants evolved over time. We explore and discuss selective pressures that drive the evolution of different Ebola variants, and how they may modify the efficacy of therapeutic treatments and vaccines currently being developed. Finally, given the unprecedented size and spread of the outbreak, as well as the extended period of replication in human hosts, specific attention is given to the 2014–2015 West African outbreak variant (Makona).
UR - http://www.scopus.com/inward/record.url?scp=84948970562&partnerID=8YFLogxK
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U2 - 10.1371/journal.ppat.1005221
DO - 10.1371/journal.ppat.1005221
M3 - Review article
C2 - 26562671
AN - SCOPUS:84948970562
SN - 1553-7366
VL - 11
JO - PLoS pathogens
JF - PLoS pathogens
IS - 11
M1 - e1005221
ER -