Ebola Virus Disease: Epidemiology, Clinical Features, Management, and Prevention

Emanuele Nicastri, Gary Kobinger, Francesco Vairo, Chiara Montaldo, Leonard E.G. Mboera, Rashid Ansunama, Alimuddin Zumla, Giuseppe Ippolito

Research output: Contribution to journalReview articlepeer-review


Ebola virus disease (EVD) is a deadly zoonotic disease caused by the Ebola virus. There is no specific treatment approved for EVD. Supportive care and management of complications are mainstays of treatment. Effective outbreak control requires a multidisciplinary team effort applying case management, infection prevention and control practices, surveillance and contact tracing, a good laboratory service, safe and dignified burials, and social and community mobilization. This article highlights the epidemiology, clinical features, diagnosis, management, and prevention of EVD. The emerging diagnostic technologies, rapid viral characterization, geospatial mapping of EVD transmission, and new treatments and vaccines are discussed.

Original languageEnglish (US)
Pages (from-to)953-976
Number of pages24
JournalInfectious disease clinics of North America
Issue number4
StatePublished - Dec 2019
Externally publishedYes


  • Diagnosis
  • Ebola
  • Ebola hemorrhagic fever
  • Ebola virus diseases
  • Epidemiology
  • Prevention
  • Treatment
  • Vaccines

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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