Abstract
Advanced stages of chronic pancreatitis and pancreatic cancers (PCs) are very serious diseases with very poor prognosis. Therefore, identification of reliable and specific biomarker(s) at early stages of the diseases could be key to their early prevention and therapy. In this chapter, currently used and putative biomarkers of acute and chronic pancreatitis and PC are summarized. Total serum lipase and/or amylase are most widely used biomarkers of acute pancreatitis; lipase assay being more sensitive and specific than that of amylase. Imaging technologies provide key support for the diagnosis of both acute and chronic pancreatitis. Biomarkers of chronic pancreatitis are poorly developed and remain challenging because of impaired secretory components of exocrine pancreas. The focus of future clinical diagnosis of chronic pancreatitis and PC lies in identification of biomarkers using omics and microRNA arrays along with imaging technologies in well-defined experimental models and their validation in patients diagnosed with various stages of chronic pancreatitis and PC.
| Original language | English (US) |
|---|---|
| Title of host publication | Biomarkers in Toxicology |
| Publisher | Elsevier |
| Pages | 341-353 |
| Number of pages | 13 |
| ISBN (Electronic) | 9780128146552 |
| ISBN (Print) | 9780128146569 |
| DOIs | |
| State | Published - Jan 1 2019 |
| Externally published | Yes |
Keywords
- Acute pancreatitis
- Chronic pancreatitis
- Diagnostic biomarkers
- Functional biomarkers
- Pancreatic cancer
ASJC Scopus subject areas
- General Medicine