Dynasore puts a new spin on dynamin: a surprising dual role during vesicle formation

Sharif R. Nankoe, Sanja Sever

Research output: Contribution to journalShort surveypeer-review

Abstract

During clathrin-mediated endocytosis, dynamin promotes the formation of clathrin-coated vesicles, but its mode of action is unresolved. In a recent study, Macia and colleagues made use of dynasore, a dynamin-specific inhibitor, to show that dynamin plays a dual role in endocytosis: they confirmed that dynamin is involved in detaching fully formed coated pits from the membrane, and also propose a new role for dynamin earlier in the process at the point of invagination.

Original languageEnglish (US)
Pages (from-to)607-609
Number of pages3
JournalTrends in Cell Biology
Volume16
Issue number12
DOIs
StatePublished - Dec 2006
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology

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