Doxycycline sclerotherapy for pediatric head and neck macrocystic lymphatic malformations: A case series and review of the literature

Nausheen Jamal, Sameer Ahmed, Todd Miller, John Bent, Allan Brook, Sanjay Parikh, Ashish Ankola

Research output: Contribution to journalArticlepeer-review


Objective: (a) To evaluate the efficacy of doxycycline as a percutaneous sclerotherapy agent in pediatric head and neck macrocystic lymphatic malformations (LM) and (b) to review the literature with regard to recent developments in the treatment of lymphatic malformations using sclerotherapy. Methods: We reviewed the medical records and imaging studies of all patients who underwent percutaneous sclerotherapy of macrocystic LM of the head and neck at our institution between June 2005 and May 2010. All studies were reviewed and procedures performed by a single interventional neuroradiologist using computed tomography (CT) guidance. LM were individually cannulated, the contents aspirated, and then injected with doxycycline at concentrations of 10-20. mg/ml. Response to sclerotherapy was determined clinically. Results: Seven patients underwent a total of eight sclerotherapy treatments during the study period. Of the six patients with appropriate follow-up, 67% have experienced complete or near-complete clinical resolution of their LM (1243 days mean follow-up), while 33% have developed recurrent swelling after an initial response following a single doxycycline injection (53 days mean follow-up). Conclusions: Our institutional results, in combination with recently published findings, support the moderate efficacy and excellent safety profile of percutaneous doxycycline sclerotherapy for macrocystic lymphatic malformations.

Original languageEnglish (US)
Pages (from-to)1127-1131
Number of pages5
JournalInternational Journal of Pediatric Otorhinolaryngology
Issue number8
StatePublished - Aug 2012
Externally publishedYes


  • Doxycycline
  • Lymphangioma
  • Lymphatic malformation
  • Sclerotherapy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Otorhinolaryngology


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