Dopaminergic agents for the treatment of cocaine abuse

Miles P. Smith; Alexander Hoepping; Kenneth M. Johnson; Monika Trzcinska; Alan P. Kozikowski

doi:10.1016/S1359-6446(99)01332-X

Dopaminergic agents for the treatment of cocaine abuse

Miles P. Smith, Alexander Hoepping, Kenneth M. Johnson, Monika Trzcinska, Alan P. Kozikowski

Research output: Contribution to journal › Review article › peer-review

43 Scopus citations

Abstract

Cocaine is a major drug of abuse whose devastating effects have captured the attention of health officials and policy makers. Based upon the alarming health and crime-related costs associated with the use of this powerful reinforcing drug, immediate therapies are needed for the treatment of cocaine addiction. In this review, some of the small-molecule-based approaches that have been pursued in the search for such medications are highlighted. Because the pharmacological actions of cocaine stem laargely from its ability to block the dopamine transporter, many intervention strategies have focused on the dopaminergic pathway. Copyright (C) 1999 Elsevier Science Ltd.

Original language	English (US)
Pages (from-to)	322-332
Number of pages	11
Journal	Drug Discovery Today
Volume	4
Issue number	7
DOIs	https://doi.org/10.1016/S1359-6446(99)01332-X
State	Published - Jul 1 1999
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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10.1016/S1359-6446(99)01332-X

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abstract = "Cocaine is a major drug of abuse whose devastating effects have captured the attention of health officials and policy makers. Based upon the alarming health and crime-related costs associated with the use of this powerful reinforcing drug, immediate therapies are needed for the treatment of cocaine addiction. In this review, some of the small-molecule-based approaches that have been pursued in the search for such medications are highlighted. Because the pharmacological actions of cocaine stem laargely from its ability to block the dopamine transporter, many intervention strategies have focused on the dopaminergic pathway. Copyright (C) 1999 Elsevier Science Ltd.",

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AU - Smith, Miles P.

AU - Hoepping, Alexander

AU - Johnson, Kenneth M.

AU - Trzcinska, Monika

AU - Kozikowski, Alan P.

PY - 1999/7/1

Y1 - 1999/7/1

N2 - Cocaine is a major drug of abuse whose devastating effects have captured the attention of health officials and policy makers. Based upon the alarming health and crime-related costs associated with the use of this powerful reinforcing drug, immediate therapies are needed for the treatment of cocaine addiction. In this review, some of the small-molecule-based approaches that have been pursued in the search for such medications are highlighted. Because the pharmacological actions of cocaine stem laargely from its ability to block the dopamine transporter, many intervention strategies have focused on the dopaminergic pathway. Copyright (C) 1999 Elsevier Science Ltd.

AB - Cocaine is a major drug of abuse whose devastating effects have captured the attention of health officials and policy makers. Based upon the alarming health and crime-related costs associated with the use of this powerful reinforcing drug, immediate therapies are needed for the treatment of cocaine addiction. In this review, some of the small-molecule-based approaches that have been pursued in the search for such medications are highlighted. Because the pharmacological actions of cocaine stem laargely from its ability to block the dopamine transporter, many intervention strategies have focused on the dopaminergic pathway. Copyright (C) 1999 Elsevier Science Ltd.

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ER -

Dopaminergic agents for the treatment of cocaine abuse

Abstract

ASJC Scopus subject areas

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