Abstract
Objective To determine if preincubation with prostaglandin E1 (PGE1) and E2 (PGE2) enhances oxytocin-induced myometrial contractility in vitro. Study Design Myometrial strips from 13 women were incubated with PGE1 (10-5 mol/L or 10-6 mol/L), PGE2 (10-5 mol/L or 10-6 mol/L) or solvent before adding cumulative concentrations of oxytocin (10 -10 to 10-6 mol/L). The area under the contraction curve was calculated after addition of each agent. One- and two-way analysis of variance was used for comparison (significance p < 0.05). Results PGE2 10-5 mol/L reduced response to oxytocin 10-9 to 10 -6 mol/L (p < 0.05). PGE2 reduced spontaneous myometrial contractility as compared with PGE1 (p < 0.05). A dose-dependent negative effect of prostaglandins was detected on oxytocin 10-8 mol/L (10 -5 mol/L > 10-6 mol/L; p < 0.05). Conclusion Contrary to the hypothesis, neither PGE1 nor PGE2 enhanced oxytocin-induced myometrial contractility; in fact, PGE2 decreased contractility.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 649-654 |
| Number of pages | 6 |
| Journal | American Journal of Perinatology |
| Volume | 30 |
| Issue number | 8 |
| DOIs | |
| State | Published - 2013 |
Keywords
- organ chamber
- oxytocin
- prostaglandin E1
- prostaglandin E2
- uterine contractility
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Obstetrics and Gynecology