Does peripartum infection increase the incidence of cerebral palsy in extremely low birthweight infants?

Maged M. Costantine, Helen Y. How, Kristin Coppage, Rose A. Maxwell, Baha M. Sibai

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Objectives: This study was undertaken to determine the perinatal predictors of cerebral palsy in extremely low birthweight infants (<1000 g). Study Design: A case control study of infants with birthweight of less than 1000 g (19 with cerebral palsy and 38 controls) who survived beyond 18-22 months of corrected age was performed. Outcome variables included maternal demographics, obstetric complications, and neonatal outcome (gestational age at delivery, birthweight, Apgar scores, intrauterine growth restriction, respiratory distress syndrome, intraventricular hemorrhage, and neonatal sepsis). Data analysis consisted of t tests, χ2, and analysis of variance when appropriate. Results: There were no significant differences between cerebral palsy and control groups with regard to mode of delivery, Apgar scores, preeclampsia, antenatal vaginal bleeding, or the use of magnesium sulfate. However, male gender (odds ratio 3.70; 95% CI 1.05-12.5), primigravid status (odds ratio 5.52; 95% CI 1.67-18.3), early neonatal sepsis (odds ratio 12.9; 95% CI 2.94-57.2) and chorioamnionitis, both clinical and histologic (odds ratio 3.71; 95% CI 1.16-11.9) were significantly associated with the development of cerebral palsy. The strong association between cerebral palsy and chorioamnionitis, as well as early neonatal sepsis, remain significant after adjustment for primigravid status and male gender. Conclusion: In extremely low birthweight infants, cerebral palsy was strongly associated with chorioamnionitis, early neonatal sepsis, male gender, and primigravid status.

Original languageEnglish (US)
Pages (from-to)e6-e8
JournalAmerican journal of obstetrics and gynecology
Issue number5
StatePublished - May 2007
Externally publishedYes


  • cerebral palsy
  • chorioamnionitis
  • extremely low birthweight

ASJC Scopus subject areas

  • Obstetrics and Gynecology


Dive into the research topics of 'Does peripartum infection increase the incidence of cerebral palsy in extremely low birthweight infants?'. Together they form a unique fingerprint.

Cite this