DNA damage induced by peroxynitrite: Subsequent biological effects

Csaba Szabó; Hiroshi Ohshima

doi:10.1006/niox.1997.0143

DNA damage induced by peroxynitrite: Subsequent biological effects

Csaba Szabó, Hiroshi Ohshima

Research output: Contribution to journal › Review article › peer-review

371 Scopus citations

Abstract

Nitric oxide (NO) and superoxide rapidly react to yield peroxynitrite. Peroxynitrite is a potent oxidant which reacts with proteins, lipids, and DNA. The present paper overviews the various DNA modifications induced by exposure to peroxynitrite or NO and superoxide concurrently, with special reference to the formation of 8-nitroguanine and 8-oxoguanine as well as the induction of DNA single strand breakage. In addition, we review the secondary processes that may follow the process of DNA damage, such as activation of the nuclear enzyme, poly(ADP-ribose) synthetase, apoptosis, and carcinogenesis.

Original language	English (US)
Pages (from-to)	373-385
Number of pages	13
Journal	Nitric Oxide - Biology and Chemistry
Volume	1
Issue number	5
DOIs	https://doi.org/10.1006/niox.1997.0143
State	Published - Oct 1997
Externally published	Yes

Keywords

8- oxoguanine
8-nitroguanine
Apoptosis
Cancer
DNA strand break
Diabetes
Endotoxin
Free radical
Inflammation
Nitric oxide
Peroxynitrite
Poly(ADP-ribose) synthetase
Septic shock
Stroke
Superoxide

ASJC Scopus subject areas

Biochemistry
Physiology
Clinical Biochemistry
Cancer Research

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10.1006/niox.1997.0143

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title = "DNA damage induced by peroxynitrite: Subsequent biological effects",

abstract = "Nitric oxide (NO) and superoxide rapidly react to yield peroxynitrite. Peroxynitrite is a potent oxidant which reacts with proteins, lipids, and DNA. The present paper overviews the various DNA modifications induced by exposure to peroxynitrite or NO and superoxide concurrently, with special reference to the formation of 8-nitroguanine and 8-oxoguanine as well as the induction of DNA single strand breakage. In addition, we review the secondary processes that may follow the process of DNA damage, such as activation of the nuclear enzyme, poly(ADP-ribose) synthetase, apoptosis, and carcinogenesis.",

keywords = "8- oxoguanine, 8-nitroguanine, Apoptosis, Cancer, DNA strand break, Diabetes, Endotoxin, Free radical, Inflammation, Nitric oxide, Peroxynitrite, Poly(ADP-ribose) synthetase, Septic shock, Stroke, Superoxide",

author = "Csaba Szab{\'o} and Hiroshi Ohshima",

note = "Funding Information: This work was supported, in part, by a grant from the National Institutes of Health (R29GM54773) to C.S.",

year = "1997",

month = oct,

doi = "10.1006/niox.1997.0143",

language = "English (US)",

volume = "1",

pages = "373--385",

journal = "Nitric Oxide - Biology and Chemistry",

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publisher = "Academic Press Inc.",

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}

TY - JOUR

T1 - DNA damage induced by peroxynitrite

T2 - Subsequent biological effects

AU - Szabó, Csaba

AU - Ohshima, Hiroshi

N1 - Funding Information: This work was supported, in part, by a grant from the National Institutes of Health (R29GM54773) to C.S.

PY - 1997/10

Y1 - 1997/10

N2 - Nitric oxide (NO) and superoxide rapidly react to yield peroxynitrite. Peroxynitrite is a potent oxidant which reacts with proteins, lipids, and DNA. The present paper overviews the various DNA modifications induced by exposure to peroxynitrite or NO and superoxide concurrently, with special reference to the formation of 8-nitroguanine and 8-oxoguanine as well as the induction of DNA single strand breakage. In addition, we review the secondary processes that may follow the process of DNA damage, such as activation of the nuclear enzyme, poly(ADP-ribose) synthetase, apoptosis, and carcinogenesis.

AB - Nitric oxide (NO) and superoxide rapidly react to yield peroxynitrite. Peroxynitrite is a potent oxidant which reacts with proteins, lipids, and DNA. The present paper overviews the various DNA modifications induced by exposure to peroxynitrite or NO and superoxide concurrently, with special reference to the formation of 8-nitroguanine and 8-oxoguanine as well as the induction of DNA single strand breakage. In addition, we review the secondary processes that may follow the process of DNA damage, such as activation of the nuclear enzyme, poly(ADP-ribose) synthetase, apoptosis, and carcinogenesis.

KW - 8- oxoguanine

KW - 8-nitroguanine

KW - Apoptosis

KW - Cancer

KW - DNA strand break

KW - Diabetes

KW - Endotoxin

KW - Free radical

KW - Inflammation

KW - Nitric oxide

KW - Peroxynitrite

KW - Poly(ADP-ribose) synthetase

KW - Septic shock

KW - Stroke

KW - Superoxide

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U2 - 10.1006/niox.1997.0143

DO - 10.1006/niox.1997.0143

M3 - Review article

C2 - 9441908

AN - SCOPUS:0031423789

SN - 1089-8603

VL - 1

SP - 373

EP - 385

JO - Nitric Oxide - Biology and Chemistry

JF - Nitric Oxide - Biology and Chemistry

IS - 5

ER -

DNA damage induced by peroxynitrite: Subsequent biological effects

Abstract

Keywords

ASJC Scopus subject areas

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