TY - JOUR
T1 - DNA-associated click chemistry
AU - Haque, Mohammad Mojibul
AU - Peng, Xiaohua
N1 - Funding Information:
We are grateful for the financial support from the UWM Research Growth Initiative (RGI101X234), the Greater Milwaukee Foundation (Shaw Scientist Award), and the National Cancer Institute (1R15CA152914-01). We thank all of our collaborators and co-workers whose names appear in the reference list.
PY - 2014/2
Y1 - 2014/2
N2 - This review highlights the most recent advances in click chemistry associated with DNA. Cu[I]-catalyzed azides-alkynes Huisgen cycloadditions (CuAAC) and a strain-promoted alkyne-azide cycloaddition (SPAAC) are two popular click reactions that have great impact in DNA science. The simplicity, versatility, orthogonality, and high efficiency of click reaction along with a stable triazole product have been instrumental for the successful application of this reaction in the field of nucleic acid chemistry. CuAAC and SPAAC reactions have been widely used for DNA modification, including DNA labeling, metallization, conjugation, cross-linking, and ligation. Modified oligodeoxynucleotides obtained from click reaction have been extensively applied in the fields of drug discovery, nanotechnology, bio-conjugation, and material sciences, among others. The most recent advances in the synthesis and applications of clickable DNAs are discussed in detail in this article.
AB - This review highlights the most recent advances in click chemistry associated with DNA. Cu[I]-catalyzed azides-alkynes Huisgen cycloadditions (CuAAC) and a strain-promoted alkyne-azide cycloaddition (SPAAC) are two popular click reactions that have great impact in DNA science. The simplicity, versatility, orthogonality, and high efficiency of click reaction along with a stable triazole product have been instrumental for the successful application of this reaction in the field of nucleic acid chemistry. CuAAC and SPAAC reactions have been widely used for DNA modification, including DNA labeling, metallization, conjugation, cross-linking, and ligation. Modified oligodeoxynucleotides obtained from click reaction have been extensively applied in the fields of drug discovery, nanotechnology, bio-conjugation, and material sciences, among others. The most recent advances in the synthesis and applications of clickable DNAs are discussed in detail in this article.
KW - "click" chemistry
KW - DNA functionalization
KW - DNA ligation and cross-linking
KW - oligodeoxynucleotides
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U2 - 10.1007/s11426-013-5035-1
DO - 10.1007/s11426-013-5035-1
M3 - Article
AN - SCOPUS:84893874006
SN - 1674-7291
VL - 57
SP - 215
EP - 231
JO - Science China Chemistry
JF - Science China Chemistry
IS - 2
ER -