Abstract
The objective of this study was to quantitate and characterize the variants of bombesin-like immunoreactivity in the alimentary canal of the rat, rabbit, hawk, owl, dog, monkey and human. Bombesin-like immunoreactivity was found throughout the entire gastrointestinal tract of all species studied. In the rat, the highest concentration of bombesin-like immunoreactivity was found in the colon. Gel chromatography showed that bombesin-like immunoreactivity corresponded to gastrin-releasing peptide (GRP-27) and GRP-10. In the dog, the greatest concentration of bombesin-like immunoreactivity was observed in the mucosal layer of the fundus, whereas the concentration of bombesin-like immunoreactivity in the muscle layer of the dog did not vary significantly from region to region. Gel chromatography showed that bombesin-like immunoreactivity in the dog corresponded to GRP-27, bombesin, GRP-10, and a smaller fragment. In the human, the concentration of bombesin-like immunoreactivity did not vary significantly from region to region in the mucosal and muscular layers. Gel chromatography of human fundal mucosa showed that bombesin-like immunoreactivity peaks occur in the regions of GRP-27, bombesin and GRP-10. These findings substantiate the observation that bombesin-like peptides play a variety of roles in the regulation of gut function.
Original language | English (US) |
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Pages (from-to) | 169-181 |
Number of pages | 13 |
Journal | Regulatory Peptides |
Volume | 16 |
Issue number | 2 |
DOIs | |
State | Published - Dec 22 1986 |
Externally published | Yes |
Keywords
- bombesin
- gastrin-releasing peptide
- gut
- vertebrates
ASJC Scopus subject areas
- Endocrinology
- Cellular and Molecular Neuroscience
- Physiology
- Biochemistry
- Clinical Biochemistry