Disseminated histoplasma capsulatum infection presenting as genital ulcerations

Michael B. Smith, Vicki J. Schnadig, Paul Zaharopoulos, Catherine Van Hook

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Background: Histoplasma capsulatum infection in adults is most often subclinical but can result in disseminated disease with weight loss, fever, hepatosplenomegaly, and oropharyngeal ulcerations. Genital ulceration as the presenting sign of the disease has been reported rarely. Case: A 63-year-old woman presented with multiple vaginal ulcerations due to chronic disseminated H capsulatum infection. Initial diagnosis was made by Papanicolaou and Giemsa-stained vulvar smears. Ketoconazole therapy resulted in clearing of the lesions in 5 weeks. Conclusion: Chronic disseminated histoplasmosis is an insidious and potentially fatal disease that can present rarely as genital mucocutaneous ulcerations in women. Prompt presumptive diagnosis can be accomplished by examination of smears obtained by ulcer abrasion, permitting institution of appropriate therapy.

Original languageEnglish (US)
Pages (from-to)842-844
Number of pages3
JournalObstetrics and gynecology
Issue number5 II SUPPL.
StatePublished - May 1997

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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