Disruption of placental homeostasis leads to preeclampsia

Akitoshi Nakashima; Tomoko Shima; Sayaka Tsuda; Aiko Aoki; Mihoko Kawaguchi; Satoshi Yoneda; Akemi Yamaki-Ushijima; Shi Bin Cheng; Surendra Sharma; Shigeru Saito

doi:10.3390/ijms21093298

Disruption of placental homeostasis leads to preeclampsia

Akitoshi Nakashima, Tomoko Shima, Sayaka Tsuda, Aiko Aoki, Mihoko Kawaguchi, Satoshi Yoneda, Akemi Yamaki-Ushijima, Shi Bin Cheng, Surendra Sharma, Shigeru Saito

Research output: Contribution to journal › Review article › peer-review

Abstract

Placental homeostasis is directly linked to fetal well-being and normal fetal growth. Placentas are sensitive to various environmental stressors, including hypoxia, endoplasmic reticulum stress, and oxidative stress. Once placental homeostasis is disrupted, the placenta may rebel against the mother and fetus. Autophagy is an evolutionally conservative mechanism for the maintenance of cellular and organic homeostasis. Evidence suggests that autophagy plays a crucial role throughout pregnancy, including fertilization, placentation, and delivery in human and mouse models. This study reviews the available literature discussing the role of autophagy in preeclampsia.

Original language	English (US)
Article number	3298
Journal	International journal of molecular sciences
Volume	21
Issue number	9
DOIs	https://doi.org/10.3390/ijms21093298
State	Published - May 1 2020
Externally published	Yes

Keywords

Autophagy
Endoplasmic reticulum stress
Inflammation
Lysosomes
Placenta
Preeclampsia
Protein aggregation
Pyroptosis

ASJC Scopus subject areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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10.3390/ijms21093298

Cite this

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title = "Disruption of placental homeostasis leads to preeclampsia",

abstract = "Placental homeostasis is directly linked to fetal well-being and normal fetal growth. Placentas are sensitive to various environmental stressors, including hypoxia, endoplasmic reticulum stress, and oxidative stress. Once placental homeostasis is disrupted, the placenta may rebel against the mother and fetus. Autophagy is an evolutionally conservative mechanism for the maintenance of cellular and organic homeostasis. Evidence suggests that autophagy plays a crucial role throughout pregnancy, including fertilization, placentation, and delivery in human and mouse models. This study reviews the available literature discussing the role of autophagy in preeclampsia.",

keywords = "Autophagy, Endoplasmic reticulum stress, Inflammation, Lysosomes, Placenta, Preeclampsia, Protein aggregation, Pyroptosis",

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AU - Nakashima, Akitoshi

AU - Shima, Tomoko

AU - Tsuda, Sayaka

AU - Aoki, Aiko

AU - Kawaguchi, Mihoko

AU - Yoneda, Satoshi

AU - Yamaki-Ushijima, Akemi

AU - Cheng, Shi Bin

AU - Sharma, Surendra

AU - Saito, Shigeru

PY - 2020/5/1

Y1 - 2020/5/1

N2 - Placental homeostasis is directly linked to fetal well-being and normal fetal growth. Placentas are sensitive to various environmental stressors, including hypoxia, endoplasmic reticulum stress, and oxidative stress. Once placental homeostasis is disrupted, the placenta may rebel against the mother and fetus. Autophagy is an evolutionally conservative mechanism for the maintenance of cellular and organic homeostasis. Evidence suggests that autophagy plays a crucial role throughout pregnancy, including fertilization, placentation, and delivery in human and mouse models. This study reviews the available literature discussing the role of autophagy in preeclampsia.

AB - Placental homeostasis is directly linked to fetal well-being and normal fetal growth. Placentas are sensitive to various environmental stressors, including hypoxia, endoplasmic reticulum stress, and oxidative stress. Once placental homeostasis is disrupted, the placenta may rebel against the mother and fetus. Autophagy is an evolutionally conservative mechanism for the maintenance of cellular and organic homeostasis. Evidence suggests that autophagy plays a crucial role throughout pregnancy, including fertilization, placentation, and delivery in human and mouse models. This study reviews the available literature discussing the role of autophagy in preeclampsia.

KW - Autophagy

KW - Endoplasmic reticulum stress

KW - Inflammation

KW - Lysosomes

KW - Placenta

KW - Preeclampsia

KW - Protein aggregation

KW - Pyroptosis

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DO - 10.3390/ijms21093298

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JO - International journal of molecular sciences

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Disruption of placental homeostasis leads to preeclampsia

Abstract

Keywords

ASJC Scopus subject areas

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