Disruption of placental homeostasis leads to preeclampsia

Akitoshi Nakashima, Tomoko Shima, Sayaka Tsuda, Aiko Aoki, Mihoko Kawaguchi, Satoshi Yoneda, Akemi Yamaki-Ushijima, Shi Bin Cheng, Surendra Sharma, Shigeru Saito

Research output: Contribution to journalReview articlepeer-review


Placental homeostasis is directly linked to fetal well-being and normal fetal growth. Placentas are sensitive to various environmental stressors, including hypoxia, endoplasmic reticulum stress, and oxidative stress. Once placental homeostasis is disrupted, the placenta may rebel against the mother and fetus. Autophagy is an evolutionally conservative mechanism for the maintenance of cellular and organic homeostasis. Evidence suggests that autophagy plays a crucial role throughout pregnancy, including fertilization, placentation, and delivery in human and mouse models. This study reviews the available literature discussing the role of autophagy in preeclampsia.

Original languageEnglish (US)
Article number3298
JournalInternational journal of molecular sciences
Issue number9
StatePublished - May 1 2020
Externally publishedYes


  • Autophagy
  • Endoplasmic reticulum stress
  • Inflammation
  • Lysosomes
  • Placenta
  • Preeclampsia
  • Protein aggregation
  • Pyroptosis

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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