TY - JOUR
T1 - Diabetes outcomes in heart failure patients with hypertrophic cardiomyopathy
AU - Mekhaimar, Menatalla
AU - Al Mohannadi, Moza
AU - Dargham, Soha
AU - Al Suwaidi, Jassim
AU - Jneid, Hani
AU - Abi Khalil, Charbel
N1 - Publisher Copyright:
Copyright © 2022 Mekhaimar, Al Mohannadi, Dargham, Al Suwaidi, Jneid and Abi Khalil.
PY - 2022/11/11
Y1 - 2022/11/11
N2 - Aims: We aimed to assess diabetes outcomes in heart failure (HF) patients with hypertrophic cardiomyopathy (HCM). Methods: The National Inpatient Sample database was analyzed to identify records from 2005 to 2015 of patients hospitalized for HF with concomitant HCM. We examined the prevalence of diabetes in those patients, assessed the temporal trend of in-hospital mortality, ventricular fibrillation, atrial fibrillation, and cardiogenic shock and compared diabetes patients to their non-diabetes counterparts. Results: Among patients with HF, 0.26% had HCM, of whom 29.3% had diabetes. Diabetes prevalence increased from 24.8% in 2005 to 32.7% in 2015. The mean age of patients with diabetes decreased from 71 ± 13 to 67.6 ± 14.2 (p < 0.01), but the prevalence of cardiovascular risk factors significantly increased. In-hospital mortality decreased from 4.3% to 3.2% between 2005 and 2015. Interestingly, cardiogenic shock, VF, and AF followed an upward trend. Age (OR = 1.04 [1.03–1.05]), female gender (OR = 1.50 [0.72–0.88]), and cardiovascular risk factors were associated with a higher in-hospital mortality risk in diabetes. Compared to non-diabetes patients, the ones with diabetes were younger and had more comorbidities. Unexpectedly, the adjusted risks of in-hospital mortality (aOR = 0.88 [0.76–0.91]), ventricular fibrillation (aOR = 0.79 [0.71–0.88]) and atrial fibrillation (aOR 0.80 [0.76–0.85]) were lower in patients with diabetes, but not cardiogenic shock (aOR 1.01 [0.80–1.27]). However, the length of stay was higher in patients with diabetes, and so were the total charges per stay. Conclusion: In total, we observed a temporal increase in diabetes prevalence among patients with HF and HCM. However, diabetes was paradoxically associated with lower in-hospital mortality and arrhythmias.
AB - Aims: We aimed to assess diabetes outcomes in heart failure (HF) patients with hypertrophic cardiomyopathy (HCM). Methods: The National Inpatient Sample database was analyzed to identify records from 2005 to 2015 of patients hospitalized for HF with concomitant HCM. We examined the prevalence of diabetes in those patients, assessed the temporal trend of in-hospital mortality, ventricular fibrillation, atrial fibrillation, and cardiogenic shock and compared diabetes patients to their non-diabetes counterparts. Results: Among patients with HF, 0.26% had HCM, of whom 29.3% had diabetes. Diabetes prevalence increased from 24.8% in 2005 to 32.7% in 2015. The mean age of patients with diabetes decreased from 71 ± 13 to 67.6 ± 14.2 (p < 0.01), but the prevalence of cardiovascular risk factors significantly increased. In-hospital mortality decreased from 4.3% to 3.2% between 2005 and 2015. Interestingly, cardiogenic shock, VF, and AF followed an upward trend. Age (OR = 1.04 [1.03–1.05]), female gender (OR = 1.50 [0.72–0.88]), and cardiovascular risk factors were associated with a higher in-hospital mortality risk in diabetes. Compared to non-diabetes patients, the ones with diabetes were younger and had more comorbidities. Unexpectedly, the adjusted risks of in-hospital mortality (aOR = 0.88 [0.76–0.91]), ventricular fibrillation (aOR = 0.79 [0.71–0.88]) and atrial fibrillation (aOR 0.80 [0.76–0.85]) were lower in patients with diabetes, but not cardiogenic shock (aOR 1.01 [0.80–1.27]). However, the length of stay was higher in patients with diabetes, and so were the total charges per stay. Conclusion: In total, we observed a temporal increase in diabetes prevalence among patients with HF and HCM. However, diabetes was paradoxically associated with lower in-hospital mortality and arrhythmias.
KW - NIS database
KW - cardiovascular disease
KW - diabetes
KW - diabetes
KW - heart failure
KW - heart failure
KW - hypertrophic cardiomyopathy
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U2 - 10.3389/fphys.2022.976315
DO - 10.3389/fphys.2022.976315
M3 - Article
AN - SCOPUS:85142654116
SN - 1664-042X
VL - 13
JO - Frontiers in Physiology
JF - Frontiers in Physiology
M1 - 976315
ER -