TY - JOUR
T1 - Dexmedetomidine alters the cardiovascular response during infra-renal aortic cross-clamping in sevoflurane-anesthetized dogs
AU - Braz, Leandro G.
AU - Braz, José R.Cerqueira
AU - Castiglia, Yara M.Mac Hado
AU - Vianna, Pedro T.Galvão
AU - Vane, Luiz A.
AU - Módolo, Norma S.Pinheiro
AU - Do Nascimento, Paulo
AU - Da Silva, André L.
AU - Kinsky, Michael P.
N1 - Funding Information:
Address correspondence to Leandro G. Braz, MD, PhD, Department of Anesthesiology, Botucatu Medical School, UNESP, Distrito de Rubião Jr, PO Box 530, Botucatu – SP, Brazil, 18618-970.E-mail: [email protected] The authors thank Assistant Professor Lidia Raquel de Carvalho from the Department of Biostatics, Institute of Biosciences, UNESP, Botucatu, São Paulo State, Brazil, for her assistance with the statistical analysis. L.G. Braz was granted a scholarship from CAPES and A.L. Silva was granted a scholarship from PIBIC/CNPq.
PY - 2008
Y1 - 2008
N2 - Some properties of the volatile anesthetics, such as vasodilatation and myocardial depression, combined with the sympathetic inhibition that α2-agonists can produce, may determine hemodynamic alterations during aortic surgery. The interaction between dexmedetomidine (DEX), an α2-agonist, and sevoflurane during aortic surgery is unknown. We studied the effects of DEX on hemodynamics and systemic oxygenation during aortic cross-clamping (Aox) and unclamping (UAox) in sevoflurane-anesthetized dogs. Twenty dogs were anesthetized with sevoflurane and were randomly assigned to two groups prior to Aox and UAox: control, n=10, received saline infusion only, and DEX (1 μg.kg-1 load followed by 1 μg.kg-1.h -1 infusion), n=10. Hemodynamic and oxygenation variables were measured at baseline, after saline or DEX loading dose, 20 and 40 min after Aox, and 20 and 40 min after UAox. After DEX administration, heart rate, cardiac index (CI) and systemic oxygen transport index (DO2I) were lower than in control group. Aox increased mean arterial pressure (MAP) and systemic vascular resistance index (SVRI) in both groups, but the effects were greater with DEX. CI, heart rate, and DO2I were lower, while central venous pressure (CVP) and pulmonary artery occlusion pressure were higher in DEX compared to control. After UAox, MAP, CVP and SVRI were maintained higher in DEX in relation to control. We conclude that in sevoflurane-anesthetized dogs DEX alters the cardiovascular response during aortic surgery.
AB - Some properties of the volatile anesthetics, such as vasodilatation and myocardial depression, combined with the sympathetic inhibition that α2-agonists can produce, may determine hemodynamic alterations during aortic surgery. The interaction between dexmedetomidine (DEX), an α2-agonist, and sevoflurane during aortic surgery is unknown. We studied the effects of DEX on hemodynamics and systemic oxygenation during aortic cross-clamping (Aox) and unclamping (UAox) in sevoflurane-anesthetized dogs. Twenty dogs were anesthetized with sevoflurane and were randomly assigned to two groups prior to Aox and UAox: control, n=10, received saline infusion only, and DEX (1 μg.kg-1 load followed by 1 μg.kg-1.h -1 infusion), n=10. Hemodynamic and oxygenation variables were measured at baseline, after saline or DEX loading dose, 20 and 40 min after Aox, and 20 and 40 min after UAox. After DEX administration, heart rate, cardiac index (CI) and systemic oxygen transport index (DO2I) were lower than in control group. Aox increased mean arterial pressure (MAP) and systemic vascular resistance index (SVRI) in both groups, but the effects were greater with DEX. CI, heart rate, and DO2I were lower, while central venous pressure (CVP) and pulmonary artery occlusion pressure were higher in DEX compared to control. After UAox, MAP, CVP and SVRI were maintained higher in DEX in relation to control. We conclude that in sevoflurane-anesthetized dogs DEX alters the cardiovascular response during aortic surgery.
KW - Aortic cross-clamping
KW - Dexmedetomidine
KW - Dog
KW - Hemodynamics
KW - Oxygen transport
KW - Sevoflurane
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U2 - 10.1080/08941930802440803
DO - 10.1080/08941930802440803
M3 - Article
C2 - 19160146
AN - SCOPUS:61749102511
SN - 0894-1939
VL - 21
SP - 360
EP - 368
JO - Journal of Investigative Surgery
JF - Journal of Investigative Surgery
IS - 6
ER -