Deterministic modeling of interferon-beta signaling pathway

Jaroslaw Smieja, Mohammad Jamaluddin, Allan Brasier, Marek Kimmel

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations


The paper is concerned with dynamical modeling of early and late gene expression in one of Interferon-β induced signaling pathways. First, the biological background is given. Subsequently, the importance of stochastic nature of biological processes is addressed. Then, the assumptions underlying their deterministic modeling are presented and the mathematical model is introduced. Finally, the methodology for identification of model parameters is briefly described, followed by the presentation of experimental and simulation results. In addition to analysis of the particular regulatory network, this work also builds a framework for modeling of other signalling pathways whose not all components are known.

Original languageEnglish (US)
Title of host publication6th IFAC Symposium on Modeling and Control in Biomedical Systems, MCBMS 2006
PublisherIFAC Secretariat
Number of pages6
EditionPART 1
ISBN (Print)9783902661180
StatePublished - 2006

Publication series

NameIFAC Proceedings Volumes (IFAC-PapersOnline)
NumberPART 1
ISSN (Print)1474-6670


  • Biocybernetics
  • Biomedical systems
  • Dynamic modelling
  • Feedback systems

ASJC Scopus subject areas

  • Control and Systems Engineering


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