Design and synthesis of some new quinoline-3-carbohydrazone derivatives as potential antimycobacterial agents

Sumesh Eswaran; Airody Vasudeva Adhikari; Nishith K. Pal; Imran H. Chowdhury

doi:10.1016/j.bmcl.2009.12.045

Design and synthesis of some new quinoline-3-carbohydrazone derivatives as potential antimycobacterial agents

Sumesh Eswaran, Airody Vasudeva Adhikari, Nishith K. Pal, Imran H. Chowdhury

Research output: Contribution to journal › Article › peer-review

Abstract

A series of 26 new quinoline derivatives carrying active pharmacophores has been synthesized and evaluated for their in vitro antituberculosis activity against Mycobacterium tuberculosis H37Rv (MTB), Mycobacterium smegmatis (MC²), and Mycobacterium fortuitum following the broth micro dilution assay method. Compounds 13e, 13i, 13k, 14a, 14c, 14i, and 14k exhibited significant minimum inhibition concentrations, when compared with first line drugs isoniazid (INH) and rifampicin (RIF) and could be ideally suited for further modifications to obtain more efficacious compounds in the fight against multi-drug resistant tuberculosis.

Original language	English (US)
Pages (from-to)	1040-1044
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	20
Issue number	3
DOIs	https://doi.org/10.1016/j.bmcl.2009.12.045
State	Published - Feb 1 2010
Externally published	Yes

Keywords

(3R)-3-Amino-N,N-dimethyl-4-(phenylthio)butanamide
Antituberculosis activity
Quinoline-3-carbohydrazone
TMC 207

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2009.12.045

Cite this

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abstract = "A series of 26 new quinoline derivatives carrying active pharmacophores has been synthesized and evaluated for their in vitro antituberculosis activity against Mycobacterium tuberculosis H37Rv (MTB), Mycobacterium smegmatis (MC2), and Mycobacterium fortuitum following the broth micro dilution assay method. Compounds 13e, 13i, 13k, 14a, 14c, 14i, and 14k exhibited significant minimum inhibition concentrations, when compared with first line drugs isoniazid (INH) and rifampicin (RIF) and could be ideally suited for further modifications to obtain more efficacious compounds in the fight against multi-drug resistant tuberculosis.",

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AU - Adhikari, Airody Vasudeva

AU - Pal, Nishith K.

AU - Chowdhury, Imran H.

PY - 2010/2/1

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Design and synthesis of some new quinoline-3-carbohydrazone derivatives as potential antimycobacterial agents

Abstract

Keywords

ASJC Scopus subject areas

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