Dermal scatter reduction in human skin: A method using controlled application of glycerol

Matthew A. Fox, Dayna G. Diven, Karen Sra, Adam Boretsky, Tasneem Poonawalla, Allison Readinger, Massoud Motamedi, Roger J. McNichols

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Background and Objective: Previous studies in a hairless Guinea pig model showed that transdermal application of glycerol effected a temporary reduction in dermal scatter of light. This study focuses on the application of this protocol on human patients. Study Design/Materials and Methods: After stratum corneal removal, glycerol was applied to human subjects using a low pressure transdermal application device. Optical coherence tomography imaging showed increased intensity of radiation reaching deeper regions in the skin and photographs showed enhanced visualization of dermal structures. Results/Conclusion: Topically applied glycerol increased light penetration of in vivo corneal-stripped skin. This minimally invasive approach to temporary dermal scatter reduction has the potential to improve the efficacy of light-based diagnostic or therapeutic devices. Lasers Surg.

Original languageEnglish (US)
Pages (from-to)251-255
Number of pages5
JournalLasers in Surgery and Medicine
Issue number4
StatePublished - Apr 2009


  • Dermal scatter reduction
  • Glycerol
  • Optical clearing
  • Skin
  • Tattoo removal
  • Transdermal

ASJC Scopus subject areas

  • Surgery
  • Dermatology


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