Demographic and regional trends of peripheral artery disease-related mortality in the United States, 2000 to 2019

Rochell Issa, Salik Nazir, Abdul Mannan Khan Minhas, Jacob Lang, Robert W. Ariss, Waleed Tallat Kayani, Mirza Umair Khalid, Laurence Sperling, Michael D. Shapiro, Hani Jneid, Rajesh Gupta

Research output: Contribution to journalArticlepeer-review


Introduction: Peripheral artery disease (PAD) is a common progressive atherosclerotic disease associated with significant morbidity and mortality in the US; however, data regarding PAD-related mortality trends are limited. This study aims to characterize contemporary trends in mortality across sociodemographic and regional groups. Methods: The Centers for Disease Control and Prevention Wide-Ranging OnLine Data for Epidemiologic Research (CDC WONDER) was queried for data regarding PAD-related deaths from 2000 to 2019 in the overall sample and different demographic (age, sex, race/ethnicity) and regional (state, urban–rural) subgroups. Crude and age-adjusted mortality rates (CMR and AAMR, respectively) per 100,000 people were calculated. Associated annual percentage changes (APC) were computed using Joinpoint Regression Program Version trend analysis software. Results: Between 2000 and 2019, a total of 1,959,050 PAD-related deaths occurred in the study population. Overall, AAMR decreased from 72.8 per 100,000 in 2000 to 32.35 per 100,000 in 2019 with initially decreasing APCs followed by no significant decline from 2016 to 2019. Most demographic and regional subgroups showed initial declines in AAMRs during the study period, with many groups exhibiting no change in mortality in recent years. However, men, non-Hispanic (NH) Black or African American individuals, people aged ⩾ 85 years, and rural counties were associated with the highest AAMRs of their respective subgroups. Notably, there was an increase in crude mortality rate among individuals 25–39 years of age from 2009 to 2019. Conclusion: Despite initial improvement, PAD-related mortality has remained stagnant in recent years. Disparities have persisted across several demographic and regional groups, requiring further investigation.

Original languageEnglish (US)
Pages (from-to)205-213
Number of pages9
JournalVascular Medicine
Issue number3
StatePublished - Jun 2023
Externally publishedYes


  • epidemiology
  • health disparities
  • mortality
  • peripheral artery disease (PAD)

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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