Abstract
Deficiencies in the quantitative expression of CD45RA and CD45RO on CD4+ and CD8+ T cells and in a population of CD45RAlowCD45ROlow T cells in blood from term newborn infants were found by flow cytometry. The relative frequencies of CD45RO on CD4+ T cells from adults and newborn infants were 72 and 58%, respectively. However, in newborn infants greater than 70% of T cells expressing CD45RO also expressed CD45RA. In addition, the quantitative expression of CD45RA and CD45RO on newborn T cells was significantly less than that found on adult blood T cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 128-132 |
| Number of pages | 5 |
| Journal | Neonatology |
| Volume | 69 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1996 |
| Externally published | Yes |
Keywords
- Blood T lymphocytes
- CD45 isoforms
- CD45 isoforms
- Newborn infants
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Developmental Biology