Deciphering flavivirus–host interactions using quantitative proteomics

Minghua Li, Holly Ramage, Sara Cherry

Research output: Contribution to journalReview articlepeer-review


Flaviviruses are a group of important emerging and re-emerging human pathogens that cause worldwide epidemics with thousands of deaths annually. Flaviviruses are small, enveloped, positive-sense, single-stranded RNA viruses that are obligate intracellular pathogens, relying heavily on host cell machinery for productive replication. Proteomic approaches have become an increasingly powerful tool to investigate the mechanisms by which viruses interact with host proteins and manipulate cellular processes to promote infection. Here, we review recent advances in employing quantitative proteomics techniques to improve our understanding of the complex interplay between flaviviruses and host cells. We describe new findings on our understanding of how flaviviruses impact protein–protein interactions, protein–RNA interactions, protein abundance, and post-translational modifications to modulate viral infection.

Original languageEnglish (US)
Pages (from-to)90-97
Number of pages8
JournalCurrent Opinion in Immunology
StatePublished - Oct 2020
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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