Abstract
Recent data suggest that D-serine is the endogenousligand for the 'glycine' binding site of theN-methyl-D-aspartate (NMDA) subtype ofglutamate receptor. This chapter reviews evidencethat this is the case, not only in brain, butalso in the retina. Information is provided documentingthe location of D-serine and serineracemase, in retinal Müller glial cells. The transportof D-serine by these cells is discussed. Newevidence demonstrating that D-serine and serineracemase are present in retinal neurons isprovided, along with data evaluating the effectsof excess D-serine on retinal neuronal viability.
| Original language | English (US) |
|---|---|
| Title of host publication | Amino Acids in Human Nutrition and Health |
| Publisher | CABI Publishing |
| Pages | 137-149 |
| Number of pages | 13 |
| ISBN (Print) | 9781845937980 |
| State | Published - Nov 24 2011 |
| Externally published | Yes |
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology
- General Medicine
- General Agricultural and Biological Sciences